典型文献
Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress
文献摘要：
The negative effects of low temperature can readily induce a variety of diseases. We sought to understand the reasons why cold stress induces disease by studying the mechanisms of fine-tuning in macrophages following cold exposure. We found that cold stress triggers increased macrophage activation accompanied by metabolic reprogramming of aerobic glycolysis. The discovery, by genome-wide RNA sequencing, of defective mitochondria in mice macrophages following cold exposure indicated that mitochondrial defects may contribute to this process. In addition, changes in metabolism drive the differentiation of macrophages by affecting histone modifications. Finally, we showed that histone acetylation and lactylation are modulators of macrophage differentiation following cold exposure. Collectively, metabolism-related epigenetic modifications are essential for the differentiation of macrophages in cold-stressed mice, and the regulation of metabolism may be crucial for alleviating the harm induced by cold stress.
文献关键词：
中图分类号：
作者姓名：
Jingjing LU;Shoupeng FU;Jie DAI;Jianwen HU;Shize LI;Hong JI;Zhiquan WANG;Jiahong YU;Jiming BAO;Bin XU;Jingru GUO;Huanmin YANG
作者机构：
College of Animal Science and Veterinary Medicine,Heilongjiang Bayi Agricultural University,Daqing 163319,China;College of Veterinary Medicine,Jilin University,Changchun 130062,China;Shanghai Bioprofile Co.Ltd.,Shanghai 201100,China;Faculty of Agricultural,Life and Environmental Sciences,University of Alberta,Edmonton,Alberta T5J 4P6,Canada
引用格式：
[1]Jingjing LU;Shoupeng FU;Jie DAI;Jianwen HU;Shize LI;Hong JI;Zhiquan WANG;Jiahong YU;Jiming BAO;Bin XU;Jingru GUO;Huanmin YANG-.Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(06):461-480
A类：
lactylation
B类：
Integrated,metabolism,epigenetic,modifications,macrophages,mice,responses,cold,negative,effects,temperature,can,readily,variety,diseases,We,sought,understand,reasons,why,induces,by,studying,mechanisms,fine,tuning,following,exposure,found,that,triggers,increased,activation,accompanied,metabolic,reprogramming,aerobic,glycolysis,discovery,genome,wide,sequencing,defective,indicated,mitochondrial,defects,may,contribute,this,process,addition,changes,drive,differentiation,affecting,histone,Finally,showed,acetylation,are,modulators,Collectively,related,essential,stressed,regulation,be,crucial,alleviating,harm,induced
AB值：
0.541063
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
