典型文献
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
文献摘要：
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases.Accumulating evidence shows multiple links between mitochondrial dysfunction and neuroinflammation.Mitochondrial-derived damage-associated molecular patterns(DAMPs)are recognized by immune receptors of microglia and aggravate neuroinflammation.On the other hand,inflammatory factors released by activated glial cells trigger an intracellular cascade,which regulates mitochondrial metabolism and function.The crosstalk between mitochondrial dysfunction and neuroinflammatory activation is a complex and dynamic process.There is strong evidence that mitochondrial dysfunction precedes neuroinflammation during the progression of diseases.Thus,an in-depth understanding of the specific molecular mechanisms associated with mitochondrial dysfunction and the progression of neuroinflammation in neurodegenerative diseases may contribute to the identification of new targets for the treatment of diseases.In this review,we describe in detail the DAMPs that induce or aggravate neuroinflammation in neurodegenerative diseases including mtDNA,mitochondrial unfolded protein response(mtUPR),mitochondrial reactive oxygen species(mtROS),adenosine triphosphate(ATP),transcription factor A mitochondria(TFAM),cardiolipin,cytochrome c,mitochondrial Ca2+and iron.
文献关键词：
中图分类号：
作者姓名：
Miao-miao Lin;Na Liu;Zheng-hong Qin;Yan Wang
作者机构：
Department of Pharmacology and Laboratory of Aging and Nervous Diseases and Jiangsu Key Laboratory of Neuropsychiatric Diseases,College of Pharmaceutical Sciences,Soochow University,Suzhou 215123,China
文献出处：
引用格式：
[1]Miao-miao Lin;Na Liu;Zheng-hong Qin;Yan Wang-.Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases)[J].中国药理学报（英文版）,2022(10):2439-2447
A类：
mtUPR,cardiolipin
B类：
Mitochondrial,derived,damage,associated,molecular,patterns,amplify,neuroinflammation,neurodegenerative,diseases,Both,mitochondrial,dysfunction,are,implicated,neurodegeneration,Accumulating,evidence,shows,multiple,links,between,DAMPs,recognized,by,immune,receptors,microglia,aggravate,On,other,hand,factors,released,activated,glial,cells,trigger,intracellular,cascade,which,regulates,metabolism,crosstalk,neuroinflammatory,activation,complex,dynamic,process,There,strong,that,precedes,during,progression,Thus,depth,understanding,specific,mechanisms,may,contribute,identification,new,targets,treatment,In,this,review,describe,detail,induce,including,mtDNA,unfolded,protein,response,reactive,oxygen,species,mtROS,adenosine,triphosphate,ATP,transcription,TFAM,cytochrome,Ca2+and,iron
AB值：
0.562923
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
