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典型文献
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury
文献摘要:
Oscillating field stimulation(OFS)is a potential method for treating spinal cord injury.Although it has been used in spinal cord injury(SCI)therapy in basic and clinical studies,its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood.In this study,we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS.The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks.The underlying mechanism may be related to the effects of OFS on promoting axon regeneration,inhibiting astrocyte proliferation,and improving the linear arrangement of astrocytes.This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University(supplemental approval No.AEEI-2021-204)on July 26,2021.
文献关键词:
作者姓名:
Yi-Xin Wang;Jin-Zhu Bai;Zhen Lyu;Guang-Hao Zhang;Xiao-Lin Huo
作者机构:
Department of Spine and Spinal Cord Surgery,Beijing Bo'ai Hospital,Rehabilitation Research Center,Beijing,China;School of Rehabilitation Medicine,Capital Medical University,Beijing,China;Beijing Key Laboratory of Bioelectromagnetism,Institute of Electrical Engineering,Chinese Academy of Sciences,Beijing,China;School of Electronics,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing,China
引用格式:
[1]Yi-Xin Wang;Jin-Zhu Bai;Zhen Lyu;Guang-Hao Zhang;Xiao-Lin Huo-.Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury)[J].中国神经再生研究(英文版),2022(06):1318-1323
A类:
AEEI
B类:
Oscillating,field,stimulation,promotes,axon,regeneration,locomotor,recovery,after,spinal,cord,injury,OFS,potential,method,treating,Although,has,been,used,SCI,therapy,basic,clinical,studies,its,underlying,mechanism,correlation,between,duration,nerve,repair,remain,poorly,understood,In,this,study,established,models,contusion,T10,then,administered,weeks,results,revealed,that,effectively,function,required,continuous,more,than,may,related,effects,promoting,inhibiting,proliferation,improving,linear,arrangement,astrocytes,This,was,approved,by,Animal,Experiments,Experimental,Welfare,Committee,Capital,Medical,University,supplemental,approval,No,July
AB值:
0.625299
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