Background : A safe, effective, and ethically sound animal model is essential for pre-clinical research to investigate spinal medical devices. We report the initial failure of a porcine spinal survival model and a potential solution by fixating the spine.Methods : Eleven female Dutch Landrace pigs underwent a spinal lumbar interlaminar de-compression with durotomy and were randomized for implantation of a medical device or control group. Magnetic resonance imaging (MRI) was performed before termination. Results : Neurological deficits were observed in 6 out of the first 8 animals. Three of these animals were terminated prematurely because they reached the predefined humane endpoint. Spinal cord compression and myelopathy was observed on postop-erative MRI imaging. We hypothesized postoperative spinal instability with epidural hematoma, inherent to the biology of the model, and subsequent spinal cord injury as a potential cause. In the subsequent 3 animals, we fixated the spine with Lubra plates. All these animals recovered without neurological deficits. The extent of spinal cord compression on MRI was variable across animals and did not seem to correspond well with neurological outcome. Conclusion : This study shows that in a porcine i n vivo model of interlaminar decom-pression and durotomy, fixation of the spine after lumbar interlaminar decompression is feasible and may improve neurological outcomes. Additional research is necessary to evaluate this hypothesis.

Emma M.H.Slot;Bart de Boer;Saskia Redegeld;Sander van Thoor;Nizar Moayeri;Willem-Bart Slooff;Irene A.Schaafsma;Bj?rn Meij;Tristan P.C.van Doormaal

Department of Neurology and Neurosurgery,University Medical Center Utrecht,Utrecht,The Netherlands;Department of Neurosurgery,Elizabeth TweeSteden Hospital,Tilburg,The Netherlands;Brain Technology Institute,Utrecht,The Netherlands;Department of Clinical Sciences,Faculty of Veterinary Medicine , Utrecht University , Utrecht , The Netherlands

动物模型与实验医学（英文）

[1]Emma M.H.Slot;Bart de Boer;Saskia Redegeld;Sander van Thoor;Nizar Moayeri;Willem-Bart Slooff;Irene A.Schaafsma;Bj?rn Meij;Tristan P.C.van Doormaal-.Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injur y)[J].动物模型与实验医学（英文）,2022(02):153-160

injur,ethically,fixating,durotomy,postop,Lubra

Spinal,fixation,after,laminectomy,pigs,prevents,postoperative,spinal,cord,Background,safe,effective,sound,model,essential,clinical,research,investigate,medical,devices,We,report,initial,failure,porcine,survival,potential,solution,by,spine,Methods,Eleven,female,Dutch,Landrace,underwent,lumbar,interlaminar,were,randomized,implantation,control,group,Magnetic,resonance,imaging,was,performed,before,termination,Results,Neurological,deficits,observed,first,animals,Three,these,terminated,prematurely,because,they,reached,predefined,humane,endpoint,myelopathy,hypothesized,instability,epidural,hematoma,inherent,biology,subsequent,injury,In,fixated,plates,All,recovered,without,neurological,extent,variable,across,did,not,seem,correspond,well,Conclusion,This,study,shows,that,vivo,decompression,feasible,may,improve,outcomes,Additional,necessary,evaluate,this,hypothesis

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