典型文献
Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects
文献摘要：
Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects, it has many clinical limitations. As an alternative, various tissue-engineered nerve grafts have been developed to substitute for autologous nerves. In this study, a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats. The novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath, reduced atrophy of the target muscle, and effectively restored neurological function. When the epineurium of the small autogenous nerve was removed, the degree of nerve regeneration was similar to that which occurs after autogenous nerve transplantation. These findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve scaffolds. The study was approved by the Research Ethics Committee of Peking University People's Hospital (approval No. 2019PHE27) on October 18, 2019.
文献关键词：
中图分类号：
作者姓名：
Bo Wang
作者机构：
Department of Orthopedics and Trauma,Key Laboratory of Trauma and Neural Regeneration(Ministry of Education/Peking University),Peking UniversityPeople's Hospital,Beijing,China;Department of Orthopedics,Chinese PLA General Hospital,Beijing,China;National Clinical Research Center for Orthopedics,Sports Medicine&Rehabilitation,Beijing,China
文献出处：
引用格式：
[1]Bo Wang-.Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects)[J].中国神经再生研究（英文版）,2022(05):1106-1114
A类：
epineurium,2019PHE27
B类：
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AB值：
0.559694
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
