典型文献
Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls
文献摘要：
Background: Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.Methods: This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants (41 GWI-cases, 40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific model. Results: Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample, as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate (OP) nerve gas was a strong predictor for lower MDA level in veterans with GWI.Conclusions: Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.
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中图分类号：
作者姓名：
Beatrice Alexandra Golomb;Sridevi Devaraj;Alexis K.Messner;Hayley Jean Koslik;Jun Hee Han;Barnabas Yik
作者机构：
Department of Medicine, School of Medicine, University of California,San Diego, La Jolla, CA 92093, USA;Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA;Swedish Medical Center, Seattle, WA 98109, USA;Henry M. Jackson Foundation for the Advancement of Military Medicine, San Diego, CA 92134, USA;Santa Clara Valley Medical Center, San Jose, CA 95128,USA
文献出处：
引用格式：
[1]Beatrice Alexandra Golomb;Sridevi Devaraj;Alexis K.Messner;Hayley Jean Koslik;Jun Hee Han;Barnabas Yik-.Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls)[J].军事医学研究（英文）,2022(02):205-214
A类：
veterans
B类：
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AB值：
0.536756
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