典型文献
Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes
文献摘要：
Background::Corneal confocal microscopy (CCM) is a noninvasive technique to detect early nerve damage of diabetic sensorimotor polyneuropathy (DSPN). Time in range (TIR) is an emerging metric of glycemic control which was reported to be associated with diabetic complications. We sought to explore the relationship between TIR and corneal nerve parameters in asymptomatic patients with type 2 diabetes (T2DM).Methods::In this cross-sectional study, 206 asymptomatic inpatients with T2DM were recruited. After 7 days of continuous glucose monitoring, the TIR was calculated as the percentage of time in the glucose range of 3.9 to 10.0 mmol/L. CCM was performed to determine corneal nerve fiber density, corneal nerve branch density, and corneal nerve fiber length (CNFL). Abnormal CNFL was defined as ≤15.30 mm/mm
2.
Results::Abnormal CNFL was found in 30.6% (63/206) of asymptomatic subjects. Linear regression analyses revealed that TIR was positively correlated with CCM parameters both in the crude and adjusted models (all
P < 0.05). Each 10% increase in TIR was associated with a 28.2% (95% CI: 0.595–0.866,
P = 0.001) decreased risk of abnormal CNFL after adjusting for covariates. With the increase of TIR quartiles, corneal nerve fiber parameters increased significantly (all
P for trend <0.01). The receiver operating characteristic curve indicated that the optimal cutoff point of TIR was 77.5% for predicting abnormal CNFL in asymptomatic patients.
Conclusions::There is a significant independent correlation between TIR and corneal nerve fiber loss in asymptomatic T2DM patients. TIR may be a useful surrogate marker for early diagnosis of DSPN.
文献关键词：
Continuous glucose monitoring;Corneal confocal microscopy;Time in range;Type 2 diabetes
中图分类号：
作者姓名：
Zhao Weijing;Lu Jingyi;Zhang Lei;Lu Wei;Zhu Wei;Bao Yuqian;Zhou Jian
作者机构：
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China;Shanghai Clinical Center for Metabolic Diseases, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China;Department of Endocrinology and Metabolism, Jinshan Branch of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 201500, China
文献出处：
引用格式：
[1]Zhao Weijing;Lu Jingyi;Zhang Lei;Lu Wei;Zhu Wei;Bao Yuqian;Zhou Jian-.Relationship between time in range and corneal nerve fiber loss in asymptomatic patients with type 2 diabetes)[J].中华医学杂志（英文版）,2022(16):1978-1985
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B类：
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,Results,found,subjects,Linear,regression,analyses,revealed,that,positively,correlated,both,crude,adjusted,models,all,Each,decreased,risk,abnormal,after,adjusting,covariates,With,quartiles,increased,significantly,trend,receiver,operating,characteristic,curve,indicated,optimal,cutoff,point,predicting,Conclusions,There,independent,correlation,may,useful,surrogate,marker,diagnosis,Continuous,Type
AB值：
0.498365
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