典型文献
Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury
文献摘要：
Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees. Inflammatory factors, including interleukin-6, interleukin-8, and tumor necrosis factor α, are also good biomarkers for the diagnosis of acute and chronic SCI, while non-coding RNAs (microRNAs and long non-coding RNAs) also show diagnostic potential for SCI. Trace elements (Mg, Se, Cu, Zn) have been shown to be related to motor recovery and can predict motor function after SCI, while humoral markers can reflect the pathophysiological changes after SCI. These factors have the advantages of low cost, convenient sampling, and ease of dynamic tracking, but are also associated with disadvantages, including diverse influencing factors and complex level changes. Although various proteins have been verified as potential biomarkers for SCI, more convincing evidence from large clinical and prospective studies is thus required to identify the most valuable diagnostic and prognostic biomarkers for SCI.
文献关键词：
中图分类号：
作者姓名：
Hong-Da Wang
作者机构：
Department of Orthopedics,Tianjin Medical University General Hospital,Tianjin,China;International Science and Technology Cooperation Base of SpinalCord Injury,Tianjin Key Laboratory of Spine and Spinal Cord,Tianjin Medical University General Hospital,Tianjin,China;Department of Orthopedics,QiluHospital,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China;Shandong University Center for Orthopedics,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China
文献出处：
引用格式：
[1]Hong-Da Wang-.Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury)[J].中国神经再生研究（英文版）,2022(05):963-971
A类：
biofluid,SCIs
B类：
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AB值：
0.585586
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