典型文献
Diabetic retinopathy: neurovascular disease requiring neuroprotective and regenerative therapies
文献摘要：
It is well known that diabetic retinopathy is a neurovascular disease that is accompanied by dysfunction of neurovascular units composed of neurons, glial cells, and vascular cells (Antonetti et al., 2012; Figure 1). Many studies have reported that the neuronal abnormalities, such as neuronal cell death, frequently precedes vascular abnormalities including neovascularization (Sohn et al., 2016). Neuronal cell death and axonal degeneration are irreversible changes under normal physiological conditions, and they are directly linked to the vision decrease. In fact, there is a reduction of the thickness of retinal nerve fiber layer in patients without diabetic retinopathy (Sohn et al., 2016). The reduction in the thickness of the ganglion cell complex, which is made up of the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer, is 0.54 μm/year which is similar to the reduction observed in advanced glaucoma (Sohn et al., 2016). These clinical findings strongly indicated that the axonal degeneration is associated with the pathogenesis of neuronal abnormalities in diabetic retinas. Thus, not only neuroprotection but also regenerative therapies are required for the protection and maintenance of visual function of eyes with diabetic retinopathy.
文献关键词：
中图分类号：
作者姓名：
Toshiyuki Oshitari
作者机构：
Department of Ophthalmology and Visual Science,Chiba University Graduate School of Medicine,Inohana, Chuo-ku, Chiba;Department of Ophthalmology, International University of Health and Welfare School of Medicine, Kozunomori, Narita, Chiba, Japan
文献出处：
引用格式：
[1]Toshiyuki Oshitari-.Diabetic retinopathy: neurovascular disease requiring neuroprotective and regenerative therapies)[J].中国神经再生研究（英文版）,2022(04):795-796
A类：
Antonetti,Sohn
B类：
Diabetic,retinopathy,neurovascular,disease,requiring,neuroprotective,regenerative,therapies,It,well,known,that,diabetic,accompanied,by,dysfunction,units,composed,neurons,glial,cells,Figure,Many,studies,have,reported,neuronal,abnormalities,such,death,frequently,precedes,nbsp,including,neovascularization,Neuronal,axonal,degeneration,are,irreversible,changes,under,physiological,conditions,they,directly,linked,vision,decrease,In,fact,there,reduction,thickness,retinal,nerve,fiber,layer,patients,without,ganglion,complex,which,made,up,inner,plexiform,year,similar,observed,advanced,glaucoma,These,clinical,findings,strongly,indicated,associated,pathogenesis,retinas,Thus,not,only,neuroprotection,but,also,required,maintenance,visual,eyes
AB值：
0.535253
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