Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological conditions. Via this route, several molecules (e.g., nucleic acids, proteins, metabolites) can be transferred to proximal and distant targets to convey specific information. Extracellular vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating cell. Indeed, circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded proteins. Furthermore, the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic development. The increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues, such as the brain, thereby serving as a "brain liquid biopsy". The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized approaches. Here, we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases (i.e., Parkinson's and Alzheimer's diseases). A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.

Anna Picca

Fondazione Policlinico Universitario"Agostino Gemelli"IRCCS,Rome,Italy;Aging Research Center,Department of Neurobiology,Care Sciences and Society,Karolinska Institutet and Stockholm University,Stockholm,Sweden;Department of Biological and Environmental Sciences and Technologies,Universitàdel Salento,Lecce,Italy;UniversitàCattolica del Sacro Cuore,Institute of Internal Medicine and Geriatrics,Rome,Italy

中国神经再生研究（英文版）

[1]Anna Picca-.Circulating extracellular vesicles: friends and foes in neurodegeneration)[J].中国神经再生研究（英文版）,2022(03):534-542

foes

Circulating,extracellular,vesicles,friends,neurodegeneration,Extracellular,have,been,identified,pivotal,mediators,intercellular,communication,critical,roles,physiological,pathological,conditions,Via,this,route,several,molecules,nucleic,acids,proteins,metabolites,can,transferred,proximal,distant,targets,convey,specific,information,associated,cargo,proposed,their,potential,tracking,down,generating,Indeed,circulating,may,represent,biomarkers,dysfunctional,quality,control,systems,especially,characterized,accrual,intracellular,misfolded,Furthermore,identification,tools,delivery,other,diseased,tissues,makes,these,shuttles,possible,therapeutic,development,increasing,interest,study,resides,mainly,fact,that,peripheral,levels,might,reflect,molecular,events,occurring,hardly,accessible,such,brain,thereby,serving,liquid,biopsy,exploitation,diagnostic,purposed,offer,unprecedented,opportunities,personalized,approaches,Here,we,discuss,bright,dark,setting,two,neurodegenerative,diseases,Parkinson,Alzheimer,focus,will,placed,possibility,using,enable,treatment,monitoring

0.595581