典型文献
Influence of Sox protein SUMOylation on neural development and regeneration
文献摘要：
SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involved in several neurological diseases. Post-translational modification of Sox proteins is known to alter their functions in the central nervous system. Among the different types of post-translational modification, small ubiquitin-like modifier (SUMO) modification of Sox proteins has been shown to modify their transcriptional activity. Here, we review the mechanisms of three Sox proteins in neuronal development and disease, along with their transcriptional changes under SUMOylation. Across three species, lysine is the conserved residue for SUMOylation. In Drosophila, SUMOylation of SoxN plays a repressive role in transcriptional activity, which impairs central nervous system development. However, deSUMOylation of SoxE and Sox11 plays neuroprotective roles, which promote neural crest precursor formation in Xenopus and retinal ganglion cell differentiation as well as axon regeneration in the rodent. We further discuss a potential translational therapy by SUMO site modification using AAV gene transduction and Clustered regularly interspaced short palindromic repeats-Cas9 technology. Understanding the underlying mechanisms of Sox SUMOylation, especially in the rodent system, may provide a therapeutic strategy to address issues associated with neuronal development and neurodegeneration.
文献关键词：
中图分类号：
作者姓名：
Kun-Che Chang
作者机构：
Department of Ophthalmology,Louis J.Fox Center for Vision Restoration,University of Pittsburgh School of Medicine,Pittsburgh,PA,USA
文献出处：
引用格式：
[1]Kun-Che Chang-.Influence of Sox protein SUMOylation on neural development and regeneration)[J].中国神经再生研究（英文版）,2022(03):477-481
A类：
SoxN,deSUMOylation,SoxE,Sox11
B类：
Influence,neural,development,regeneration,SRY,related,HMG,box,factors,are,known,regulate,central,nervous,system,involved,several,neurological,diseases,Post,translational,modification,proteins,alter,their,functions,Among,types,post,small,ubiquitin,like,modifier,has,been,shown,modify,transcriptional,activity,Here,review,mechanisms,three,neuronal,along,changes,Across,species,lysine,conserved,residue,Drosophila,plays,repressive,which,impairs,However,neuroprotective,roles,promote,crest,precursor,formation,Xenopus,retinal,ganglion,cell,differentiation,well,axon,rodent,We,further,discuss,potential,therapy,by,site,using,AAV,transduction,Clustered,regularly,interspaced,short,palindromic,repeats,Cas9,technology,Understanding,underlying,especially,may,provide,therapeutic,strategy,address,issues,associated,neurodegeneration
AB值：
0.543442
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
