典型文献
Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways
文献摘要：
INTRODUCTION
Numerous clinical conditions, including inflammation, congenital malformation, cancer, aging, osteoporosis, and diabetes, can cause oral bone defects that eventually lead to aggravated bone loss and disrupted bone repair.1–4 Bacterial invasion into the pulp evokes pulpal inflammation represented by neutrophil infiltration and the sequential infiltration of macrophages and lymphocytes.5 Among the immune cells, macrophages predominate in inflamed pulp tissues and produce cytokines, such as interleukin 1β(IL-1β) and tumor necrosis factor α (TNF-α), which are particularly elevated in inflamed pulp.6–7 This evidence implies that macro-phages play a crucial role in eliciting pulpal inflammation and thereby contribute to pathologic transitions, such as oral bone defects and bone loss.
文献关键词：
中图分类号：
作者姓名：
Bongkun Choi;Ji-Eun Kim;Si-On Park;Eun-Young Kim;Soyoon Oh;Hyuksu Choi;Dohee Yoon;Hyo-Jin Min;Hyung-Ryong Kim;Eun-Ju Chang
作者机构：
Department of Biomedical Sciences,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Korea;Stem Cell Immunomodulation Research Center,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Korea;Department of Pharmacology,College of Dentistry,Jeonbuk National University,Jeonju,Korea;Department of Biochemistry and Molecular Biology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Korea
文献出处：
引用格式：
[1]Bongkun Choi;Ji-Eun Kim;Si-On Park;Eun-Young Kim;Soyoon Oh;Hyuksu Choi;Dohee Yoon;Hyo-Jin Min;Hyung-Ryong Kim;Eun-Ju Chang-.Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways)[J].国际口腔科学杂志（英文版）,2022(02):192-200
A类：
Numerous,pulpal
B类：
Sphingosine,phosphate,hinders,osteogenic,differentiation,dental,stem,cells,association,AKT,signaling,pathways,INTRODUCTION,clinical,conditions,including,inflammation,congenital,malformation,cancer,aging,osteoporosis,diabetes,cause,oral,bone,defects,that,eventually,lead,aggravated,loss,disrupted,repair,Bacterial,invasion,into,evokes,represented,neutrophil,infiltration,sequential,macrophages,lymphocytes,Among,immune,predominate,inflamed,tissues,produce,cytokines,such,interleukin,tumor,necrosis,which,are,particularly,elevated,This,evidence,implies,play,crucial,role,eliciting,thereby,contribute,pathologic,transitions
AB值：
0.635846
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
