Polysaccharides are macromolecular complexes that have various biological activities.In vivo and in vitro studies have shown that polysaccharides play neuroprotective roles through multiple mechanisms;consequently,they have potential in the prevention and treatment of neurodegenerative diseases.This paper summarizes related research published during 2015-2020 and reviews advances in the understanding of the neuroprotective effects of bioactive polysaccharides.This review focuses on 15 bioactive polysaccharides from plants and fungi that have neuroprotective properties against oxidative stress,apoptosis,neuroinflammation,and excitatory amino acid toxicity mainly through the regulation of nuclear factor kappa-B,phosphatidylinositol-3-kinase/protein kinase B,mitogen-activated protein kinase,nuclear factor-E2-related factor 2/hemeoxygenase-1,c-jun N-terminal kinase,protein kinase B-mammalian target of rapamycin,and reactive oxygen species-nucleotide-binding oligomerization domain,leucine-rich repeat and pyrin domain-containing 3 signaling pathways.Natural bioactive polysaccharides have potential in the prevention and treatment of neurodegenerative diseases because of their advantageous characteristics,including multi-targeting,low toxicity,and synergistic effects.However,most of the recent related research has focused on cell and animal models.Future randomized clinical trials involving large sample sizes are needed to validate the therapeutic benefits of these neuroprotective polysaccharides in patients having neurodegenerative diseases.

Xiao-Lan Xu;Song Li;Rong Zhang;Wei-Dong Le

Department of Neurology,Sichuan Academy of Medical Sciences-Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu,Sichuan Province,China;Liaoning Provincial Center for Clinical Research on Neurological Diseases,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning Province,China

中国神经再生研究（英文版）

[1]Xiao-Lan Xu;Song Li;Rong Zhang;Wei-Dong Le-.Neuroprotective effects of naturally sourced bioactive polysaccharides:an update)[J].中国神经再生研究（英文版）,2022(09):1907-1912

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