Hierarchical polymer brushes have been considered as an effective and promising method for preventing implant-associated infections via multiple antibacterial mechanisms.Herein,a bacterial phosphatase re-sponsive surface with hierarchical zwitterionic structures was developed for timely dealing with the poly-meric implant-associated bacterial infection.The hierarchical polymeric architecture was subtly realized on model polypropylene(PP)substrate by sequential photo living grafting of poly(2-(dimethylamino)ethyl methacrylate(PDMAEMA)bottom layer and zwitterionic poly(sulfobetaine methacrylate)(PSBMA)upper layer,followed by the conversion of the PDMAEMA into the zwitterionic structure via succes-sive quaternization and phosphorylation reactions.Owing to shielding the bottom polycations,the hi-erarchical zwitterionic polymer brushes guaranteed the surface with the optimal biocompatibility under the normal physiological environment.Once bacteria are invaded,the surface bactericidal activity of the bottom layer can be rapidly and automatically activated owing to the transition triggered by bacterial phosphatase from zwitterion to polycation.Additionally,ameliorated by the upper layer,the hierarchical surface showed obvious adhesion resistance to dead bacterial cells and notably migrated the cytotoxic-ity of exposed polycation after completion of the bactericidal task.As a proof-of-principle demonstration,this self-adaptive hierarchical surface with sensitive bacterial responsiveness and biocompatibility showed great potential in combating hernia mesh-related infection.This work provides a promising and universal strategy for the on-demand prevention of medical device-associated infections.

Liwei Sun;Lingjie Song;Xu Zhang;Shuaishuai Yuan;Shifang Luan

State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry Chinese Academy of Sciences,Changchun 130022,China;University of Science and Technology of China,Hefei 230026,China;Key Laboratory of Biobased Polymer Materials of Shandong Provincial Education Department,College of Polymer Science and Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;National Engineering Laboratory for Medical Implantable Devices,WEGO Co.Ltd.,Weihai 264210,China

材料科学技术（英文版）

[1]Liwei Sun;Lingjie Song;Xu Zhang;Shuaishuai Yuan;Shifang Luan-.Biocompatible hierarchical zwitterionic polymer brushes with bacterial phosphatase activated antibacterial activity)[J].材料科学技术（英文版）,2022(31):191-202

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