典型文献
Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era
文献摘要：
Antibiotic resistance is one of the biggest threats to global health,as it can make the treat-ment of bacterial infections in humans difficult owing to their high incidence rate,mortality,and treat-ment costs.Bacteriophage,which constitutes a type of virus that can kill bacteria,is a promising alternative strategy against antibiotic-resistant bacterial infections.Although bacteriophage therapy was first used nearly a century ago,its development came to a standstill after introducing the antibi-otics.Nowadays,with the rise in antibiotic resistance,bacteriophage therapy is in the spotlight again.As bacteriophage therapy is safe and has significant anti-bacterial activity,some specific types of bac-teriophages(such as bacteriophage phiX174 and Pyo bacteriophage complex liquid)entered into phaseⅢ clinical trials.Herein,we review the key points of the antibiotic resistance crisis and illustrate the factors that support the renewal of bacteriophage applications.By summarizing recent state-of-the-art studies and clinical data on bacteriophage treatment,we introduced(i)the pharmacological mecha-nisms and advantages of antibacterial bacteriophages,(ii)bacteriophage preparations with clinical po-tential and bacteriophage-derived anti-bacterial treatment strategies,and(iii)bacteriophage therapeutics aimed at multiple infection types and infection-induced cancer treatments.Finally,we highlighted the challenges and critical perspectives of bacteriophage therapy for future clinical devel-opment.
文献关键词：
中图分类号：
作者姓名：
Hao Ling;Xinyu Lou;Qiuhua Luo;Zhonggui He;Mengchi Sun;Jin Sun
作者机构：
Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Pharmacy,The First Affiliated Hospital of China Medical University,Shenyang 110001,China
文献出处：
引用格式：
[1]Hao Ling;Xinyu Lou;Qiuhua Luo;Zhonggui He;Mengchi Sun;Jin Sun-.Recent advances in bacteriophage-based therapeutics:Insight into the post-antibiotic era)[J].药学学报（英文版）,2022(12):4348-4364
A类：
Bacteriophage,antibi,teriophages,phiX174,Pyo
B类：
Recent,advances,therapeutics,Insight,into,post,antibiotic,Antibiotic,resistance,one,biggest,threats,global,health,make,infections,humans,difficult,owing,their,incidence,mortality,costs,which,constitutes,virus,that,kill,promising,alternative,strategy,against,resistant,Although,therapy,was,first,used,nearly,century,ago,its,development,came,standstill,after,introducing,otics,Nowadays,rise,spotlight,safe,significant,activity,some,specific,types,such,complex,liquid,entered,phase,clinical,trials,Herein,we,review,key,points,crisis,illustrate,factors,support,renewal,applications,By,summarizing,recent,state,art,studies,data,introduced,pharmacological,mecha,nisms,advantages,antibacterial,bacteriophages,preparations,tential,derived,strategies,iii,aimed,multiple,induced,cancer,treatments,Finally,highlighted,challenges,critical,perspectives,future
AB值：
0.511238
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