Anti-tumor pharmacology of natural products targeting mitosis|Manru Huang;Caiyan Liu;Yingying Shao;Shiyue Zhou;Gaoyong Hu;Shuangshuang Yin;Weiling Pu;Haiyang Yu|State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China - 期刊导航|首站-论文投稿智能助手|论文发表|论文智能投稿|期刊自助发表推荐|杂志社快速发表|查同导刊-域田数据官方网站

典型文献

Anti-tumor pharmacology of natural products targeting mitosis

文献摘要：

Cancer has been an insurmountable problem in the history of medical science. The uncontrollable proliferation of cancer cells is one of cancer's main characteristics, which is closely associated with abnormal mitosis. Targeting mitosis is an effective method for cancer treatment. This review summarizes several natural products with anti-tumor effects related to mitosis, focusing on targeting microtubulin, inducing DNA damage, and modulating mitosis-associated kinases. Furthermore, the main disadvantages of several typical compounds, including drug resistance, toxicity to non-tumor tissues, and poor aqueous solubility and pharmacokinetic properties, are also discussed, together with strategies to address them. Improved understanding of cancer cell mitosis and natural products may pave the way to drug development for the treatment of cancer.

文献关键词：

中图分类号：

[1] 医药、卫生（R） / 药学（R9） / 药理学（R96） / 实验药理学（R965）

[2] 医药、卫生（R） / 临床医学（R4） / 治疗学（R45） / 生物疗法（R456）

[3] 医药、卫生（R） / 中国医学（R2） / 中药学（R28） / 中药药理学（R285） / 中药实验药理（R285.5）

作者姓名：

Manru Huang;Caiyan Liu;Yingying Shao;Shiyue Zhou;Gaoyong Hu;Shuangshuang Yin;Weiling Pu;Haiyang Yu

作者机构：

Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Ministry of Education,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

文献出处：

癌症生物学与医学（英文版）

引用格式：

[1]Manru Huang;Caiyan Liu;Yingying Shao;Shiyue Zhou;Gaoyong Hu;Shuangshuang Yin;Weiling Pu;Haiyang Yu-.Anti-tumor pharmacology of natural products targeting mitosis)[J].癌症生物学与医学（英文版）,2022(06):774-801

A类：

microtubulin

B类：

Anti,tumor,pharmacology,natural,products,targeting,mitosis,Cancer,has,been,insurmountable,problem,history,medical,science,uncontrollable,proliferation,cancer,cells,one,main,characteristics,which,closely,associated,abnormal,Targeting,effective,method,treatment,This,review,summarizes,several,anti,effects,related,focusing,inducing,damage,modulating,kinases,Furthermore,disadvantages,typical,compounds,including,drug,resistance,toxicity,tissues,poor,aqueous,solubility,pharmacokinetic,properties,are,also,discussed,together,strategies,address,them,Improved,understanding,may,pave,way,development

AB值：

0.624417

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