典型文献
Differential roles of RIG?I like receptors in SARS?CoV?2 infection
文献摘要：
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells, the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5, RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/Ⅲ interferon (IFN) during infection was impaired in MDA5–/– and MAVS–/–, but not in RIG-I–/–, when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2), the cellular entry receptor for SARS-CoV-2, was approximately 2.5-fold higher in RIG-I–/– than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor, IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells.
文献关键词：
中图分类号：
作者姓名：
Duo?Meng Yang;Ting?Ting Geng;Andrew G.Harrison;Peng?Hua Wang
作者机构：
Department of Immunology,School of Medicine,University of Connecticut Health Center,Farmington,CT 06030,USA
文献出处：
引用格式：
[1]Duo?Meng Yang;Ting?Ting Geng;Andrew G.Harrison;Peng?Hua Wang-.Differential roles of RIG?I like receptors in SARS?CoV?2 infection)[J].军事医学研究（英文）,2022(02):262-264
A类：
B类：
Differential,roles,RIG,like,receptors,SARS,CoV,infection,Retinoic,acid,inducible,gene,melanoma,differentiation,associated,protein,MDA5,sense,activate,antiviral,immune,responses,Herein,we,investigate,their,functions,human,epithelial,cells,primary,initial,target,severe,acute,respiratory,syndrome,coronavirus,deficiency,mitochondrial,signaling,MAVS,enhanced,replication,expression,type,interferon,IFN,during,was,impaired,but,not,when,compared,wild,WT,level,full,length,angiotensin,converting,enzyme,ACE2,cellular,entry,approximately,fold,higher,than,These,data,demonstrate,predominant,sensor,independent,induction
AB值：
0.607136
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