典型文献
Antimicrobial peptides: mechanism of action, activity and clinical potential
文献摘要：
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
文献关键词：
中图分类号：
作者姓名：
Qi?Yu Zhang;Zhi?Bin Yan;Yue?Ming Meng;Xiang?Yu Hong;Gang Shao;Jun?Jie Ma;Xu?Rui Cheng;Jun Liu;Jian Kang;Cai?Yun Fu
作者机构：
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928, Street 2, Xiasha Higher Education Zone, Hangzhou 310018, China;Department of Oncology, The 903rd Hospital of PLA,Hangzhou 310013, China;Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Blvd. South, San Francisco, CA 94158, USA;Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia;Sir Peter MacCallum Department of Oncology, University of Melbourne,Parkville, VIC 3010, Australia
文献出处：
引用格式：
[1]Qi?Yu Zhang;Zhi?Bin Yan;Yue?Ming Meng;Xiang?Yu Hong;Gang Shao;Jun?Jie Ma;Xu?Rui Cheng;Jun Liu;Jian Kang;Cai?Yun Fu-.Antimicrobial peptides: mechanism of action, activity and clinical potential)[J].军事医学研究（英文）,2022(02):231-258
A类：
B类：
Antimicrobial,peptides,action,activity,clinical,potential,management,bacterial,infections,becoming,major,challenge,due,rapid,evolution,antibiotic,resistant,excellent,candidate,overcome,resistance,antimicrobial,AMPs,that,are,produced,from,synthetic,natural,sources,demonstrate,broad,spectrum,high,specificity,low,toxicity,These,possess,distinctive,structures,functions,by,employing,sophisticated,mechanisms,This,comprehensive,review,provides,overview,origin,structural,characteristics,biological,activities,applications,We,finally,discuss,strategies,optimize,develop,treatment,anticancer,therapeutics
AB值：
0.667039
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
