典型文献
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents
文献摘要：
Parthenolide(PTL)is a sesquiterpene lactone derived from medicinal plant feverfew(Tanacetum parthenium).Recent studies have demonstrated that it has multiple pharmacological activities,especially in the treatment of various hematological and sol-id cancers.The superior anticancer activity of PTL suggests that it has the potential to be a first-line drug.However,due to the limited physical and chemical properties,as well as bioavailability,structural modification strategies are strongly recommended to improve the anticancer activity.This review describes representative PTL derivatives obtained by different modification strategies,which are repor-ted to exert antiproliferative activities superior to the parent compound PTL.Furthermore,we also summarize their basic mechanisms on cancer-related signaling pathways,so as to explain the potential and characteristics of PTL and its derivatives in cancer therapy.
文献关键词：
中图分类号：
作者姓名：
LIU Xingchen;WANG Xiaobing
作者机构：
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,School of Tradi-tional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China
文献出处：
引用格式：
[1]LIU Xingchen;WANG Xiaobing-.Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents)[J].中国天然药物,2022(11):814-829
A类：
feverfew,Tanacetum,parthenium,repor
B类：
Recent,advances,structural,modification,parthenolide,its,derivatives,anticancer,agents,Parthenolide,PTL,sesquiterpene,lactone,derived,from,medicinal,plant,studies,have,demonstrated,that,has,multiple,pharmacological,activities,especially,treatment,various,hematological,sol,cancers,superior,activity,suggests,potential,first,line,drug,However,due,limited,physical,chemical,properties,well,bioavailability,strategies,strongly,recommended,improve,This,review,describes,representative,obtained,by,different,which,exert,antiproliferative,parent,compound,Furthermore,also,summarize,their,basic,mechanisms,related,signaling,pathways,explain,characteristics,therapy
AB值：
0.569774
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