典型文献
Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection
文献摘要：
To increase the efficiency and accuracy of clin-ical tumor detection,we explored multiple imaging by preparing carbon quantum dot(CQD)-loaded nanobubbles for ultrasonic fluorescence dual detec-tion.In this experiment,we prepared 1,2-dioleoyl-3-trimethylammonium-propane chloride(DOTAP)cat-ionic liposomes using the film dispersion method and chose perfluoropentane as the core gas material of the nanobubbles.The nanobubbles were coupled with the negatively charged CQDs through the charge effect to prepare the testing agent for two-way diagnosis with ultrasound contrast and fluorescence detection.The formulation and preparation of the loaded CQD lipo-some nanobubbles were screened.In vivo experiments showed that nanobubbles can be enriched to the tumor site within 5 min,which enables clearer ultra-sound imaging and is conducive to tumor detection.We expect CQD-loaded liposome(Lip-CQD)nano-bubbles to become a new ultrasonic contrast agent for clinical applications that can provide a basis for early tumor diagnosis and thus earlier treatment.
文献关键词：
中图分类号：
作者姓名：
Yankun ZHANG;Bingtao TANG;Yu XIN;Qiong WU;Lan LIU;Yunxia WANG;Kongxi ZHU;Guimei LIN;Hongjuan WANG
作者机构：
School of Pharmaceutical Science,Shandong University,Jinan 250012,China;School of Mechanical Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China;Department of Gastroenterology,the Second Hospital of Shandong University,Jinan 250033,China
引用格式：
[1]Yankun ZHANG;Bingtao TANG;Yu XIN;Qiong WU;Lan LIU;Yunxia WANG;Kongxi ZHU;Guimei LIN;Hongjuan WANG-.Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(09):778-783
A类：
trimethylammonium,perfluoropentane
B类：
Nanobubbles,loaded,carbon,quantum,dots,ultrasonic,fluorescence,dual,detection,To,increase,efficiency,accuracy,tumor,explored,multiple,imaging,by,preparing,nanobubbles,In,this,prepared,dioleoyl,propane,chloride,DOTAP,ionic,liposomes,using,film,dispersion,method,chose,core,gas,material,were,coupled,negatively,charged,CQDs,through,effect,testing,agent,two,way,diagnosis,ultrasound,contrast,formulation,preparation,screened,vivo,experiments,showed,that,can,enriched,site,within,which,enables,clearer,conducive,We,expect,Lip,become,new,clinical,applications,provide,basis,early,thus,earlier,treatment
AB值：
0.505141
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
