典型文献
From Bench to the Clinic: The Path to Translation of Nanotechnology?Enabled mRNA SARS?CoV?2 Vaccines
文献摘要：
During the last decades, the use of nanotechnology in med icine has effectively been translated to the design of drug delivery sys?tems, nanostructured tissues, diagnostic platforms, and novel nano?materials against several human diseases and infectious pathogens. Nanotechnology-enabled vaccines have been positioned as solutions to mitigate the pandemic outbreak caused by the novel pathogen severe acute respiratory syndrome coronavirus 2. To fast-track the develop?ment of vaccines, unprecedented industrial and academic collabora?tions emerged around the world, resulting in the clinical translation of effective vaccines in less than one year. In this article, we provide an overview of the path to translation from the bench to the clinic of nanotechnology-enabled messenger ribonucleic acid vaccines and examine in detail the types of delivery systems used, their mechanismsof action, obtained results during each phase of their clinical development and their regulatory approval process. We also analyze how nanotechnology is impacting global health and economy during the COVID-19 pandemic and beyond.
文献关键词：
中图分类号：
作者姓名：
Diana O.Lopez?Cantu;Xichi Wang;Hector Carrasco?Magallanes;Samson Afewerki;Xingcai Zhang;Joseph V.Bonventre;Guillermo U.Ruiz?Esparza
作者机构：
Division of Engineering in Medicine,Department of Medicine,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA;Division of Health Sciences and Technology,Harvard University-Massachusetts Institute of Technology,Boston,MA 02115,USA;Division of Renal Medicine,Department of Medicine,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,USA;Tecnologico de Monterrey,School of Engineering and Sciences,64849 Monterrey,NL,Mexico;Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,People's Republic of China;Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA;Tecnologico de Monterrey,School of Medicine and Health Sciences,64849 Monterrey,NL,Mexico;John A.Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,MA 02138,USA;School of Engineering,Massachusetts Institute of Technology,Cambridge,MA 02139,USA
文献出处：
引用格式：
[1]Diana O.Lopez?Cantu;Xichi Wang;Hector Carrasco?Magallanes;Samson Afewerki;Xingcai Zhang;Joseph V.Bonventre;Guillermo U.Ruiz?Esparza-.From Bench to the Clinic: The Path to Translation of Nanotechnology?Enabled mRNA SARS?CoV?2 Vaccines)[J].纳微快报（英文）,2022(03):1-31
A类：
mechanismsof
B类：
From,Bench,Clinic,Path,Translation,Nanotechnology,Enabled,SARS,CoV,Vaccines,During,last,decades,nanotechnology,med,icine,effectively,been,translated,design,drug,delivery,nanostructured,tissues,diagnostic,platforms,novel,materials,against,several,human,diseases,infectious,pathogens,enabled,vaccines,have,positioned,solutions,mitigate,pandemic,outbreak,caused,by,severe,acute,respiratory,syndrome,coronavirus,To,fast,track,unprecedented,industrial,academic,collabora,emerged,around,world,resulting,clinical,translation,less,than,year,In,this,article,we,provide,overview,from,bench,messenger,ribonucleic,acid,examine,detail,types,systems,their,action,obtained,results,during,each,phase,development,regulatory,approval,process,We,also,analyze,how,impacting,global,health,economy,beyond
AB值：
0.653465
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