典型文献
Molecular Insights into Striking Antibody Evasion of SARS-CoV-2 Omicron Variant
文献摘要：
The SARS-CoV-2 Omicron variant has become the dominant variant in the world.Uncovering the structural basis of altered immune response and enhanced transmission of Omicron is particularly important.Here,taking twenty-five antibodies from four groups as examples,we comprehensively reveal the underlying mechanism of how mutations in Omicron induces the weak neutralization by using molecular simulations.Overall,the binding strength of 68％antibodies is weakened in Omicron,much larger than that in Delta(40％).Specifically,the percentage of the weakened antibodies vary largely in different groups.Moreover,the mutation-induced repul-sion is mainly responsive for the weak neutralization in AB/CD groups but does not take effect in EF group.Significantly,we demonstrate that the disappearance of hydrophobic interaction and salt bridges due to residue deletions contributes to the decreased binding energy in NTD group.This work provides unprecedented atom-istic details for the distinct neutralization of WT/Delta/Omicron,which informs prospective efforts to design antibodies/vaccines against Omicron.
文献关键词：
中图分类号：
作者姓名：
Zeng-Shuai Yan;Yao Xu;Hong-Ming Ding;Yu-Qiang Ma
作者机构：
National Laboratory of Solid State Microstructures and Department of Physics,Collaborative Innovation Center of Advanced Microstructures,Nanjing University,Nanjing 210093,China;Center for Soft Condensed Matter Physics and Interdisciplinary Research,School of Physical Science and Technology,Soochow University,Suzhou 215006,China
文献出处：
引用格式：
[1]Zeng-Shuai Yan;Yao Xu;Hong-Ming Ding;Yu-Qiang Ma-.Molecular Insights into Striking Antibody Evasion of SARS-CoV-2 Omicron Variant)[J].中国物理快报（英文版）,2022(10):73-80
A类：
repul
B类：
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AB值：
0.667075
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