典型文献
Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria
文献摘要：
Carbapenem resistance presents a major challenge for the global public health network, as clinical infec-tions caused by carbapenem-resistant organisms (CRO) are frequently associated with significant mor-bidity and mortality. Ceftazidime–avibactam (CAZ–AVI) is a novel cephalosporin/β-lactamase inhibitor combination offering an important advance in the treatment of CRO infections. CAZ–AVI has been reported to inhibit the activities of Ambler classes A, C, and some class D enzymes. However, bacterial resistance has been emerging shortly after the introduction of this combination in clinical use, with an increasing trend. Understanding these resistance mechanisms is crucial for guiding the development of novel treatments and aiding in the prediction of underlying resistance mechanisms. This review aims to systematically summarize the epidemiology of CAZ–AVI-resistant strains and recently identified resis-tance mechanisms of CAZ–AVI, with a focus on the production ofβ-lactamase variants, the hyperexpres-sion ofβ-lactamases, reduced permeability, and overexpressed efflux pumps. The various mechanisms of CAZ–AVI resistance that have emerged within a short timescale emphasize the need to optimize the use of current agents, as well as the necessity for the surveillance of CAZ–AVI-resistant pathogens.
文献关键词：
中图分类号：
作者姓名：
Tingting Xu;Yuqi Guo;Yang Ji;Baohong Wang;Kai Zhou
作者机构：
Shenzhen Institute of Respiratory Diseases,Shenzhen People's Hospital&2nd Clinical Medical College of Jinan University&1st Affiliated Hospital of Southern University of Science and Technology,Shenzhen 518020,China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First
文献出处：
引用格式：
[1]Tingting Xu;Yuqi Guo;Yang Ji;Baohong Wang;Kai Zhou-.Epidemiology and Mechanisms of Ceftazidime–Avibactam Resistance in Gram-Negative Bacteria)[J].工程（英文）,2022(04):138-145
A类：
Ceftazidime,Avibactam,cephalosporin,Ambler,hyperexpres
B类：
Epidemiology,Mechanisms,Resistance,Gram,Negative,Bacteria,Carbapenem,resistance,presents,major,challenge,global,public,health,network,clinical,caused,by,carbapenem,resistant,organisms,CRO,are,frequently,associated,significant,bidity,mortality,avibactam,CAZ,AVI,novel,inhibitor,combination,offering,important,advance,infections,been,reported,activities,classes,some,enzymes,However,bacterial,emerging,shortly,after,introduction,this,increasing,trend,Understanding,these,mechanisms,crucial,guiding,development,treatments,aiding,prediction,underlying,This,review,aims,systematically,summarize,epidemiology,strains,recently,identified,focus,production,variants,sion,lactamases,reduced,permeability,overexpressed,efflux,pumps,various,that,have,emerged,within,timescale,emphasize,need,optimize,current,agents,well,necessity,surveillance,pathogens
AB值：
0.554109
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