Objective:To investigate the effect of M3P(containing Deer antler,Cordyceps sinensis,Rhodiola rosea,and Panax ginseng);an herbal remedy with the function of tonifying Kidney(Shen)and invigorating Spleen(Pi),replenishing qi and nourishing blood;on fatigue alleviation,endurance capacity and toxicity.Methods:Swimming with weight-loading of 24 male ICR mice was used to evaluate the endurance capacity,and fatigue-related plasma biomarkers were determined.Mice were randomly assigned to control or M3P treatment groups with 6 mice for each group and were orally administered with M3P everyday for 8 weeks at doses 0,10,33 or 100 mg/kg.Swimming time to exhaustion was measured in a specialized water tank.Lliver and kidney functions,body weight,and hematological profile were determined to evaluate the safety and toxicity after long-term M3P administration.Results:M3P supplementation 100 mg/kg significantly increased swimming endurance time up to approximate 2.4 folds of controls(P＜0.05).The plasma concentrations of cortisol and hepatic glycogen content were significantly increased in mice received M3P(P＜0.05,P＜0.01 respectively).The lactic acid level and blood glucose were not changed after M3P treatment(P＞0.05).The liver and kidney functions muscle damage biomarker creatine,body weight,and hemograms were not altered in M3P supplementation(P＞0.05).Conclusion:M3P supplementation may improve swimming endurance accompanied by increasing hepatic glycogen content and serum cortisol level without maior toxicitv.

CHU Chien-ming;CHI Chih-wen;HUANG Chih-hung;CHEN Yu-jen

Graduate Institute of Biochemical and Biomedical Engineering,National Taipei University of Technology,Taipei(10608),Taiwan,China;BioMedical Development Center,MacKay Memorial Hospital,New Taipei City(25160),Taiwan,China;Department of Medical Research,MacKay Memorial Hospital,New Taipei City(25160),Taiwan,China;Department of Radiation Oncology,MacKay Memorial Hospital,Taipei(10449),Taiwan,China

中国结合医学杂志（英文版）

[1]CHU Chien-ming;CHI Chih-wen;HUANG Chih-hung;CHEN Yu-jen-.Enhancement of Swimming Endurance by Herbal Supplement M3P)[J].中国结合医学杂志（英文版）,2022(08):725-729

Supplement,M3P,invigorating,Lliver,hemograms,maior,toxicitv

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