典型文献
β-Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency—A Randomized,Placebo-Controlled,and Double-Blinded Trial
文献摘要：
Objective:To test the hypothesis that β-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receive β-glucan(200 mg daily)or placebo for 12 weeks.Participants'PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was derived.Indices of participants'immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory IgA(sIgA),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between the β-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(vs.placebo)group in a time-dependent manner.The intergroup differences[95％confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(％)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),respectively.Additionally,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95％CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over placebo.Conclusions:β-Glucan ameliorates PQi in PQD individuals.By using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such as β-glucan,can be employed to advance CM therapeutics.
文献关键词：
中图分类号：
作者姓名：
WU Jun-rong;CHENG Hao-jie;SHI Jian-pin;YIN Wei-dong;WANG Jun;OU Xuan-qiao;CHEN Jin-li;Ira Bernstein;Mark Levy;Rolando Maddela;Robert Sinnott;TIAN Jun-qiang
作者机构：
Elegant and Olive Health Clinic,Markham,ON,L3R 5V6,Canada;Research and Development Department,USANA Health Science,Inc.,Salt Lake City,UT,84121,USA;Department of Family and Community Medicine,University of Toronto,Toronto,ON,M5T 2S8,Canada
文献出处：
引用格式：
[1]WU Jun-rong;CHENG Hao-jie;SHI Jian-pin;YIN Wei-dong;WANG Jun;OU Xuan-qiao;CHEN Jin-li;Ira Bernstein;Mark Levy;Rolando Maddela;Robert Sinnott;TIAN Jun-qiang-.β-Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency—A Randomized,Placebo-Controlled,and Double-Blinded Trial)[J].中国结合医学杂志（英文版）,2022(05):394-402
A类：
Blinded,PQi,pernicious
B类：
Glucan,Improves,Protective,Status,Adults,Deficiency,Randomized,Placebo,Controlled,Double,Trial,Objective,To,test,hypothesis,that,glucan,enhances,protective,qi,important,Chinese,medicine,CM,concept,which,stipulates,force,circulates,throughout,body,surface,works,first,defense,against,external,influences,Methods,total,participants,deficiency,PQD,were,randomized,receive,daily,placebo,weeks,Participants,status,was,assessed,every,via,conventional,diagnosis,standardized,protocol,from,severity,risk,derived,Indices,immune,general,health,also,monitored,including,upper,respiratory,tract,infection,URTI,saliva,secretory,sIgA,self,reported,measures,physical,mental,PROMIS,Results,not,significantly,different,between,treatment,groups,baseline,but,improved,dependent,manner,intergroup,differences,confidence,interval,scale,proportion,finish,respectively,Additionally,symptom,scores,by,magnitude,over,Conclusions,ameliorates,individuals,By,using,stringent,evidence,methodologies,our,study,demonstrated,remedies,such,employed,advance,therapeutics
AB值：
0.586397
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
