典型文献
Peripheral Delivery of Ganglioside GM1 Exacerbates the Patho-genesis of Alzheimer's Disease in a Mouse Model
文献摘要：
Dear Editor,
Alzheimer's disease (AD) is the most common cause of dementia among the older population,and is characterized by amyloid-beta (Aβ) accumulation,hyperphosphorylation of tau,and finally neurodegeneration in the brain[1].Aβ is the major pathological agent in AD,thus currently most efforts in developing therapies for AD target this peptide.The most promising therapy for this disease is immunotherapy,which shows high efficacy in improving AD-type pathology and cognition in mouse models.However,clinical trials of immunotherapy against Aβ have not yet succeeded,partly due to adverse effects.Another potent therapeutic method for AD is screening drugs currently used in clinical practice,which might significantly reduce the risk of adverse events[2].
文献关键词：
中图分类号：
作者姓名：
Chuang-Chuang Yang;Yuan Cheng;Hai-Mei Yang;Yang Chen;Yan-Jiang Wang;Zhi-Qiang Xu;Ye-Ran Wang
作者机构：
Department of Neurology and Clinical Center for Neuro-science,Daping Hospital,Third Military Medical University,Chongqing 400042,China
文献出处：
引用格式：
[1]Chuang-Chuang Yang;Yuan Cheng;Hai-Mei Yang;Yang Chen;Yan-Jiang Wang;Zhi-Qiang Xu;Ye-Ran Wang-.Peripheral Delivery of Ganglioside GM1 Exacerbates the Patho-genesis of Alzheimer's Disease in a Mouse Model)[J].神经科学通报（英文版）,2022(01):95-98
A类：
Ganglioside,Exacerbates,Patho,
Alzheimer
B类：
Peripheral,Delivery,GM1,genesis,Disease,Mouse,Model,Dear,Editor,disease,AD,most,common,cause,dementia,among,older,population,characterized,by,amyloid,beta,accumulation,hyperphosphorylation,tau,finally,neurodegeneration,brain,major,pathological,agent,thus,currently,efforts,developing,therapies,target,this,peptide,promising,immunotherapy,which,shows,high,efficacy,improving,type,pathology,cognition,mouse,models,However,clinical,trials,against,have,yet,succeeded,partly,due,adverse,effects,Another,potent,therapeutic,method,screening,drugs,used,practice,might,significantly,reduce,risk,events
AB值：
0.67573
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