典型文献
Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease
文献摘要：
Dear Editor,
Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of dementia.Synaptic loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Synaptic loss,unlike neuronal loss,is reversible due to the highly dynamic prop-erties of synapses.Thus,therapeutics targeting synaptic loss and dysfunction are practical and beneficial for treating neu-rodegenerative diseases.Most importantly,the window for the treatment of synapses is longer than that of clearing toxic proteins and preventing neuronal death.Treatment targeting synapses delivered at a relatively late stage still slows the progression of AD[2].Evidence supporting a hypothesis for targeting the excitation-inhibition(EI)synaptic balance provides a therapeutic approach for preventing neurodegen-eration in patients with AD[3].
文献关键词：
中图分类号：
作者姓名：
Yun-Long Xu;Lin Zhu;Zi-Jun Chen;Xiao-Fei Deng;Pei-Dong Liu;Shan Li;Bing-Chun Lin;Chuan-Zhong Yang;Wei Xu;Kui-Kui Zhou;Ying-Jie Zhu
作者机构：
Shenzhen Key Laboratory of Drug Addiction,Shenzhen Neher Neural Plasticity Laboratory,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences(CAS),Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China;Department of Neonatology,Shenzhen Maternity&Child Healthcare Hospital,The First School of Clinical Medicine,Southern Medical University,Shenzhen 518055,China;The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China;Cheeloo College of Medicine,Shandong University,Jinan 250012,China;Faculty of Life and Health Sciences,Shenzhen Institute of Advanced Technology,CAS,Shenzhen 518055,China;CAS Center for Excellence in Brain Science and Intelligence Technology,CAS,Shanghai 200031,China;CAS Key Laboratory of Brain Connectome and Manipulation,BCBDI,Shenzhen Institute of Advanced Technology(SIAT),CAS,Shenzhen 518055,China
文献出处：
引用格式：
[1]Yun-Long Xu;Lin Zhu;Zi-Jun Chen;Xiao-Fei Deng;Pei-Dong Liu;Shan Li;Bing-Chun Lin;Chuan-Zhong Yang;Wei Xu;Kui-Kui Zhou;Ying-Jie Zhu-.Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer's Disease)[J].神经科学通报（英文版）,2022(11):1425-1430
A类：
Entorhinal,Paraventricular,Thalamus,Deficits,
Alzheimer,rodegenerative,neurodegen
B类：
Release,Endogenous,Brain,derived,Neurotrophic,Factor,into,Lateral,Cortex,from,Ameliorates,Social,Memory,Mouse,Model,Disease,Dear,Editor,AD,one,most,devastating,neurodegenerative,disorders,common,form,dementia,Synaptic,loss,hallmark,pathology,exacerbates,cognitive,impairment,unlike,neuronal,reversible,due,highly,dynamic,prop,erties,synapses,Thus,therapeutics,targeting,synaptic,dysfunction,are,practical,beneficial,treating,diseases,Most,importantly,window,treatment,longer,than,that,clearing,toxic,proteins,preventing,death,Treatment,delivered,relatively,late,stage,still,slows,progression,Evidence,supporting,hypothesis,excitation,inhibition,EI,balance,provides,approach,eration,patients
AB值：
0.644636
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
