典型文献
Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial
文献摘要：
Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December 2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization.Patients received E+D,Zuogui Pill or BYHD for 12 months,respectively.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-Müllerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after treatment.Results:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the study.After 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all P＜0.01).BYHD also resulted in E2 elevation(P＜0.05),ovary enlargement(P＜0.05),AFC increase(P＜0.01),and RI of ovarian arteries decrease(P＜0.05).After 12 months,further improvements were observed in the Zuogui Pill and BYHD groups(all P＜0.01),but BYHD showed better outcomes,with lower FSH,larger ovaries and a thicker endometrium compared with the Zuogui Pill group(all P＜0.01).However,E+D only significantly increased endometrial thickness(P＜0.01)and no significant improvements were observed in the RI of uterine arteries in the three groups.Conclusions:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin endometrium.The combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR.
文献关键词：
中图分类号：
作者姓名：
ZHOU Jing;PAN Xin-yao;LIN Jin;ZHOU Qi;LAN Li-kun;ZHU Jun;DUAN Ru;WANG Lan;SUN Yan;WANG Ling
作者机构：
Laboratory for Reproductive Immunology,Hospital&Institute of Obstetrics and Gynecology,Shanghai Medical College,Fudan University,Shanghai 200000,China;Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200000,China;Academy of Integrative Medicine of Fudan University,Shanghai 200000,China;Yangpu Hospital of Traditional Chinese Medicine,Shanghai 200000,China;Second Affiliated Hospital of Hexi University,Zhangye,Gansu Province 743000,China;Department of Obstetrics and Gynecology,Wenling People's Hospital,Wenzhou Medical University,Wenzhou,Zhejiang Province 325000,China;Regulatory Commission Office of the New Cooperative Medical Scheme,Eryuan County,Dali,Yunnan Province 671000,China
文献出处：
引用格式：
[1]ZHOU Jing;PAN Xin-yao;LIN Jin;ZHOU Qi;LAN Li-kun;ZHU Jun;DUAN Ru;WANG Lan;SUN Yan;WANG Ling-.Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial)[J].中国结合医学杂志（英文版）,2022(03):195-201
A类：
Bushen,BYHD,progynova,duphaston,E+D,Zuogui,Rls
B类：
Effects,Yiqi,Huoxue,Decoction,Treatment,Patients,Diminished,Ovarian,Reserve,Randomized,Controlled,Trial,Objective,To,explore,therapeutic,effect,patients,diminished,ovarian,reserve,DOR,Methods,total,diagnosed,from,December,were,equally,assigned,into,Pill,cases,each,by,computerized,randomization,received,months,respectively,Follicle,stimulating,hormone,FSH,luteinizing,LH,estradiol,E2,anti,llerian,AMH,antral,follicle,count,AFC,volume,endometrial,thickness,resistance,indices,arteries,uterine,observed,before,after,treatment,Results,Nine,women,withdrew,study,After,significantly,decreased,increased,also,resulted,elevation,ovary,enlargement,RI,further,improvements,groups,but,showed,better,outcomes,lower,larger,ovaries,thicker,endometrium,compared,However,only,three,Conclusions,had,favorable,rebalancing,levels,promoting,ovulation,repairing,thin,combination,tonifying,Shen,Kidney,benefiting,activating,blood,circulation,may,promising,strategy
AB值：
0.462234
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