Objective::To explore the risk factors and pregnancy outcomes in women with a history of cesarean section complicated by placenta accreta (PA).Methods::This case-control study included clinical data from singleton mothers with a history of cesarean section in 11 public tertiary hospitals in seven provinces of China between January 2017 and December 2017. According to the intraoperative findings after delivery, the study population was divided into PA and non-PA groups. We compared the pregnancy outcomes between the two groups, used multivariate logistic regression to analyze the risk factors for placental accreta.Results::For this study we included 11,074 pregnant women with a history of cesarean section; and of these, 869 cases were in the PA group and 10,205 cases were in the non-PA group. Compared with the non-PA group, the probability of postpartum hemorrhage (236/10,205, 2.31% vs. 283/869, 32.57%), severe postpartum hemorrhage (89/10,205, 0.87% vs. 186/869, 21.75%), diffuse intravascular coagulation (3/10,205, 0.03% vs. 4/869, 0.46%), puerperal infection (33/10,205, 0.32% vs. 12/869, 1.38%), intraoperative bladder injury (1/10,205, 0.01% vs. 16/869, 1.84%), hysterectomy (130/10,205, 1.27% vs. 59/869, 6.79%), and blood transfusion (328/10,205,3.21 % vs. 231/869,26.58%) was significantly increased in the PA group ( P < 0.05). At the same time, the neonatal birth weight (3250.00 (2950.00-3520.00) g vs. 2920.00 (2530.00-3250.00) g), the probability of neonatal comorbidities (245/10,205, 2.40% vs. 61/869, 7.02%), and the rate of neonatal intensive care unit admission (817/10,205, 8.01% vs. 210/869, 24.17%) also increased significantly ( P < 0.05). Weight (odds ratio ( OR)= 1.03, 95% confidence interval ( CI): 1.01-1.05)), parity ( OR= 1.18, 95% CI: 1.03-1.34), number of miscarriages ( OR= 1.31, 95% CI: 1.17-1.47), number of previous cesarean sections ( OR= 2.57, 95% CI: 2.02-3.26), history of premature rupture of membrane ( OR= 1.61, 95% CI: 1.32-1.96), previous cesarean-section transverse incisions ( OR= 1.38, 95% CI: 1.12-1.69), history of placenta previa ( OR= 2.44,95% CI: 1.50-3.96), and the combination of prenatal hemorrhage ( OR= 9.95,95% CI: 8.42-11.75) and placenta previa ( OR= 91.74, 95% CI: 74.11-113.56) were all independent risk factors for PA. Conclusion::There was an increased risk of adverse outcomes in pregnancies complicated by PA in women with a history of cesarean section, and this required close clinical attention. Weight before pregnancy, parity, number of miscarriages, number of previous cesarean sections, history of premature rupture of membranes, past transverse incisions in cesarean sections, a history of placenta previa, prenatal hemorrhage, and placenta previa were independent risk factors for pregnancies complicated with PA in women with a history of cesarean section. These independent risk factors showed a high value in predicting the risk for placentab accreta in pregnancies of women with a history of cesarean section.

Placenta accreta;Risk factors;History of cesarean section;Pregnancy outcome

Liang Yingyu;Zhang Lizi;Bi Shilei;Chen Jingsi;Zeng Shanshan;Huang Lijun;Li Yulian;Huang Minshan;Tan Hu;Jia Jinping;Wen Suiwen;Wang Zhijian;Cao Yinli;Wang Shaoshuai;Xu Xiaoyan;Feng Ling;Zhao Xianlan;Zhao Yangyu;Zhu Qiying;Qi Hongbo;Zhang Lanzhen;Li Hongtian;Du Lili;Chen Dunjin

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510510, China;Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou 510510, China;Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Guangzhou 510510, China;Department of Obstetrics and Gynecology, Guangzhou Huadu District Maternal and Child Health Hospital, Guangzhou 510150, China;Department of Obstetrics and Gynecology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Guangzhou 511518, China;Northwest Women’s and Children’s Hospital, Xi’an 710061, China;Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China;Department ofObstetrics and Gynecology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China;Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing 100191, China

母胎医学杂志（英文）

[1]Liang Yingyu;Zhang Lizi;Bi Shilei;Chen Jingsi;Zeng Shanshan;Huang Lijun;Li Yulian;Huang Minshan;Tan Hu;Jia Jinping;Wen Suiwen;Wang Zhijian;Cao Yinli;Wang Shaoshuai;Xu Xiaoyan;Feng Ling;Zhao Xianlan;Zhao Yangyu;Zhu Qiying;Qi Hongbo;Zhang Lanzhen;Li Hongtian;Du Lili;Chen Dunjin-.Risk Factors and Pregnancy Outcome in Women with a History of Cesarean Section Complicated by Placenta Accreta)[J].母胎医学杂志（英文）,2022(03):179-185

Accreta,miscarriages,incisions,placentab

Risk,Factors,Pregnancy,Outcome,Women,History,Cesarean,Section,Complicated,by,Placenta,Objective,To,explore,risk,factors,pregnancy,outcomes,women,history,cesarean,complicated,accreta,PA,Methods,This,control,study,included,clinical,data,from,singleton,mothers,public,tertiary,hospitals,seven,provinces,China,between,January,December,According,intraoperative,findings,after,delivery,population,was,divided,into,groups,compared,two,used,multivariate,logistic,regression,analyze,placental,Results,For,this,pregnant,these,cases,were,Compared,probability,postpartum,hemorrhage,severe,diffuse,intravascular,coagulation,puerperal,infection,bladder,injury,hysterectomy,blood,transfusion,significantly,increased,At,same,neonatal,birth,weight,comorbidities,rate,intensive,care,unit,admission,also,Weight,odds,ratio,confidence,interval,parity,number,previous,sections,premature,rupture,transverse,previa,combination,prenatal,all,independent,Conclusion,There,adverse,pregnancies,required,close,attention,before,membranes,past,These,showed,high,value,predicting

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