典型文献
The role of REV-ERB in NASH
文献摘要：
REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors.The natural ligand for the REV-ERBs(REV-ERBα and REV-ERBβ)is heme,and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes.These two receptors regulate a large range of physiological processes including several important in the pathophysiology of non-alcoholic steatohepatitis(NASH).These include carbohydrate and lipid metabolism as well as inflammatory pathways.A number of synthetic REV-ERB agonists have been developed as chemical tools and they show efficacy in animal models of NASH.Here,we will review the functions of REV-ERB with regard to their relevance to NASH as well as the potential to target REV-ERB for treatment of this disease.
文献关键词：
中图分类号：
作者姓名：
Kristine Griffett;Matthew E.Hayes;Michael P.Boeckman;Thomas P.Burris
作者机构：
Center for Clinical Pharmacology,Washington University in St.Louis and University of Health Sciences&Pharmacy,St.Louis,MO 63110,USA;University of Florida Genetics Institute,Gainesville,FL 32610,USA
文献出处：
引用格式：
[1]Kristine Griffett;Matthew E.Hayes;Michael P.Boeckman;Thomas P.Burris-.The role of REV-ERB in NASH)[J].中国药理学报（英文版）,2022(05):1133-1140
A类：
ERBs,corepressor
B类：
role,REV,NASH,are,atypical,nuclear,receptors,they,ligand,regulated,transcriptional,repressors,natural,heme,binding,results,recruitment,proteins,such,CoR,that,mediates,repression,target,genes,These,two,large,range,physiological,processes,including,several,important,pathophysiology,alcoholic,steatohepatitis,include,carbohydrate,lipid,metabolism,well,inflammatory,pathways,number,synthetic,agonists,have,been,developed,chemical,tools,show,efficacy,animal,models,Here,will,review,functions,regard,their,relevance,potential,treatment,this,disease
AB值：
0.51117
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
