典型文献
Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression
文献摘要：
Hepatocellular carcinoma(HCC),the most prevalent liver cancer,is considered one of the most lethal malignancies with a dismal outcome mainly due to frequent intrahepatic and distant metastasis.In the present study,we demonstrated that oroxylin A,a natural product extracted from Scutellaria radix,significantly inhibits transforming growth factor-beta1(TGF-β1)-induced epithelial-mesenchymal transition(EMT)and metastasis in HCC.Oroxylin A blocked the TGF-β1/Smad signaling via upregulating the non-steroidal anti-inflammatory drug-activated gene-1(NAG-1)expression.Oroxylin A promoted NAG-1 transcription by regulating the acetylation of CCAAT/enhancer binding protein β(C/EBPβ),a transcription factor that binds to the NAG-1 promoter.In terms of the underlying mechanism,oroxylin A may interact with histone deacetylase 1(HDAC1)by forming hydrogen bonds with GLY149 residue and induce proteasome-mediated degradation of HDAC1 subsequently impairing HDAC1-mediated deacetylation of C/EBPβ and promoting the expression of NAG-1.Taken together,our findings revealed a previously unknown tumor-suppressive mechanism of oroxylin A.Oroxylin A should be further investigated as a potential clinical candidate for inhibiting HCC metastasis.
文献关键词：
中图分类号：
作者姓名：
Tong-xin Huo;Xiao-ping Wang;Zhou Yu;Bo Kong;Yuan He;Qing-long Guo;Xiao-bo Zhang;Lei Qiang
作者机构：
State Key Laboratory of Natural Medicines,School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China;State Key Laboratory of Natural Medicines,Jiangsu Key Laboratory of Carcinogenesis and Intervention,School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs,Institute of Dermatology,Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing 210042,China
文献出处：
引用格式：
[1]Tong-xin Huo;Xiao-ping Wang;Zhou Yu;Bo Kong;Yuan He;Qing-long Guo;Xiao-bo Zhang;Lei Qiang-.Oroxylin A inhibits the migration of hepatocellular carcinoma cells by inducing NAG-1 expression)[J].中国药理学报（英文版）,2022(03):724-734
A类：
Oroxylin,oroxylin,GLY149
B类：
inhibits,migration,hepatocellular,carcinoma,cells,by,inducing,NAG,expression,Hepatocellular,HCC,most,prevalent,liver,cancer,considered,lethal,malignancies,dismal,outcome,mainly,frequent,intrahepatic,distant,metastasis,In,present,study,we,demonstrated,that,natural,product,extracted,from,Scutellaria,radix,significantly,transforming,growth,beta1,TGF,induced,epithelial,mesenchymal,transition,EMT,blocked,Smad,signaling,via,upregulating,steroidal,anti,inflammatory,drug,activated,gene,promoted,transcription,CCAAT,enhancer,binding,protein,EBP,binds,promoter,terms,underlying,mechanism,may,interact,histone,deacetylase,HDAC1,hydrogen,bonds,residue,proteasome,mediated,degradation,subsequently,impairing,deacetylation,promoting,Taken,together,our,findings,revealed,previously,unknown,tumor,suppressive,should,further,investigated,potential,clinical,candidate,inhibiting
AB值：
0.628726
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