典型文献
Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration
文献摘要：
Transcription factors,human E26 transcription factor 1(Ets1)and specific protein 1(Sp1),are known to induce gene expression in tumorigenicity.High Ets1 expression is often associated with colorectal tumorigenesis.In this study,we discover that metastasis and clone formation in SW480 cells mainly depend on the direct interaction between Ets1 and Sp1 instead of high Ets1 expression.The interaction domains are further addressed to be the segment at Sp1(626-708)and the segment at Ets1(244-331).In addition,the phosphorylation inhibition of Ets1 at Tyr283 by either downregulation of Src kinase or Src family inhibitor treatment decreases the interaction between Sp1 and Ets1 and suppresses SW480 migration.Either administration or overexpression of the peptides harboring the interaction segment strongly inhibits the colony formation and migration of SW480 cells.Our findings suggest that the interaction between Ets1 and Sp1 rather than Ets1 alone promotes transformation in SW480 cells and provide new insight into the Ets1 and Sp1 interaction as an antitumour target in SW480 cells.
文献关键词：
中图分类号：
作者姓名：
Xianhui Wen;Xingsheng Sun;Zheyuan Ou;Jun Jiang;Qingmei Chen;Xirong He;Zhangsheng Hu;Han Qiao;Kuan Zhou;Xin Li;Yiqun Deng;Jikai Wen
作者机构：
Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms,College of Life Sciences,South China Agricultural University,Guangzhou 510642,China;Guangdong Laboratory for Lingnan Modern Agriculture,South China Agricultural University,Guangzhou 510642,China;Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs,South China Agricultural University,Guangzhou 510642,China
文献出处：
引用格式：
[1]Xianhui Wen;Xingsheng Sun;Zheyuan Ou;Jun Jiang;Qingmei Chen;Xirong He;Zhangsheng Hu;Han Qiao;Kuan Zhou;Xin Li;Yiqun Deng;Jikai Wen-.Phosphorylation-mediated interaction between human E26 transcription factor 1 and specific protein 1 is required for tumor cell migration)[J].生物化学与生物物理学报（英文版）,2022(10):1441-1452
A类：
Ets1,Tyr283
B类：
Phosphorylation,mediated,interaction,between,human,E26,transcription,specific,protein,required,migration,Transcription,factors,Sp1,are,known,induce,tumorigenicity,High,often,associated,colorectal,tumorigenesis,In,this,study,discover,that,metastasis,clone,SW480,cells,mainly,depend,direct,instead,high,domains,further,addressed,segment,addition,phosphorylation,inhibition,by,either,downregulation,Src,kinase,family,inhibitor,treatment,decreases,suppresses,Either,administration,overexpression,peptides,harboring,strongly,inhibits,colony,Our,findings,suggest,rather,than,alone,promotes,transformation,provide,new,insight,into,antitumour,target
AB值：
0.468481
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
