典型文献
Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)
文献摘要：
The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal medicine.In the current study,the antiproliferative constituents of giant taro were investigated and six new(1-6)and four known piperidine alkaloids(7-10)were isolated from its rhizomes.Their chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester method.The isolated alkaloids were screened for the antiprolifer-ative activity through MTT assay.The results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2,AGS and MCF-7 tumor cells.Further researches showed that compounds 3-5 dose-dependently decreased the colony forma-tion rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic pathway.This study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.
文献关键词：
中图分类号：
作者姓名：
GAO Wei;WANG Yi;WANG Ru;WANG Yi-Hai;XU Jing-Wen;HE Xiang-Jiu
作者机构：
School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Engineering Research Center for Lead Compounds&Drug Discovery,Guangzhou 510006,China
文献出处：
引用格式：
[1]GAO Wei;WANG Yi;WANG Ru;WANG Yi-Hai;XU Jing-Wen;HE Xiang-Jiu-.Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza))[J].中国天然药物,2022(07):541-550
A类：
Antiproliferative,piperidine,taro,Alocasia,macrorrhiza,antiprolifer
B类：
alkaloids,from,giant,Schott,which,highly,adaptable,wild,plant,traditional,Chinese,herbal,medicine,In,current,study,antiproliferative,constituents,were,investigated,six,new,four,known,isolated,its,rhizomes,Their,structures,absolute,configurations,elucidated,using,various,spectroscopic,methods,Mosher,ester,screened,activity,through,MTT,assay,results,indicated,that,exerted,potential,against,HepG2,AGS,MCF,cells,Further,researches,showed,compounds,dose,dependently,decreased,colony,forma,induced,apoptosis,while,death,via,proapoptotic,pathway,This,demonstrates,exhibit,significant,antitumor,provides,phytochemical,evidence,further,development,utilization
AB值：
0.525841
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