典型文献
ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway
文献摘要：
ACT001,derived from traditional herbal medicine,is a novel compound with effective anticancer activity in clinical trials.However,little is known regarding its role in pituitary adenomas.Here,we demonstrated that ACT001 suppressed cell proliferation and induced cell death of pituitary tumor cells in vitro and in vivo.ACT001 was also effective in suppressing the growth of different subtypes of human pituitary adenomas.The cytotoxic mechanism ACT001 employed was mainly related to autophagic cell death(ACD),indicated by autophagosome formation and LC3-Ⅱ accumulation.In addition,ACT001-mediated inhibitory effect decreased when either ATG7 was downregulated or cells were cotreated with autophagy inhibitor 3-methyladenine(3-MA).RNA-seq analysis showed that mitogen-activated protein kinase(MAPK)pathway was a putative target of ACT001.Specifically,ACT001 treatment promoted the phosphorylation of JNK and P38 by binding to mitogen-activated protein kinase kinase 4(MEK4).Our study indicated that ACT001-induced ACD of pituitary tumor cells via activating JNK and P38 phosphorylation by binding with MEK4,and it might be a novel and effective anticancer drug for pituitary adenomas.
文献关键词：
中图分类号：
作者姓名：
Lin Cai;Ze-rui Wu;Lei Cao;Jia-dong Xu;Jiang-long Lu;Cheng-de Wang;Jing-hao Jin;Zhe-bao Wu;Zhi-peng Su
作者机构：
Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China;Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;Department of Cardio-Thoracic Surgery,Zhoushan Hospital,Zhoushan 316021,China;Department of Neurosurgery,Center of Pituitary Tumor,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
文献出处：
引用格式：
[1]Lin Cai;Ze-rui Wu;Lei Cao;Jia-dong Xu;Jiang-long Lu;Cheng-de Wang;Jing-hao Jin;Zhe-bao Wu;Zhi-peng Su-.ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway)[J].中国药理学报（英文版）,2022(09):2386-2396
A类：
ACT001,MEK4
B类：
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AB值：
0.504688
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
