Developmental exposure to bisphenol A(BPA),an endocrine-disrupting contaminant,impairs cognitive function in both animals and humans.However,whether BPA affects the development of primary sensory systems,which are the first to mature in the cortex,remains largely unclear.Using the rat as a model,we aimed to record the physiological and structural changes in the primary audi-tory cortex(Al)following lactational BPA exposure and their possible effects on behavioral outcomes.We found that BPA-exposed rats showed significant behavioral impairments when performing a sound temporal rate discrimination test.A significant alteration in spectral and temporal processing was also recorded in their Al,manifested as degraded frequency selectivity and dimin-ished stimulus rate-following by neurons.These post-exposure effects were accompanied by changes in the density and maturity of dendritic spines in Al.Our findings demonstrated developmental impacts of BPA on auditory cortical processing and auditory-related discrimination,particularly in the temporal domain.Thus,the health implications for humans associated with early exposure to endocrine disruptors such as BPA merit more careful examination.

Binliang Tang;Kailin Li;Yuan Cheng;Guimin Zhang;Pengying An;Yutian Sun;Yue Fang;Hui Liu;Yang Shen;Yifan Zhang;Ye Shan;étienne de Villers-Sidani;Xiaoming Zhou

Key Laboratory of Brain Functional Genomics of Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,School of Life Sciences,East China Normal University,Shanghai 200062,China;New York University-East China Normal University Institute of Brain and Cognitive Science,NYU-Shanghai,Shanghai 200062,China;Department of Neurology and Neurosurgery,Montreal Neu-rological Institute,McGill University,Montreal,QC H3A 2B4,Canada

神经科学通报（英文版）

[1]Binliang Tang;Kailin Li;Yuan Cheng;Guimin Zhang;Pengying An;Yutian Sun;Yue Fang;Hui Liu;Yang Shen;Yifan Zhang;Ye Shan;étienne de Villers-Sidani;Xiaoming Zhou-.Developmental Exposure to Bisphenol a Degrades Auditory Cortical Processing in Rats)[J].神经科学通报（英文版）,2022(11):1292-1302

Degrades,lactational,dimin

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