典型文献
Cleavable Cys labeling directed Lys site-selective stapling and single-site modification
文献摘要:
Site-selective modification of peptide/protein is a vital approach to disclose post-translational modifications(PTMs)and plays a crucial role in chemical biology,as well as drug development.Compared with synthetic and chemical biology methods,chemical modification of native peptide/protein provides a more versatile approach to achieve late-stage diversification for functional studies.Lysine featured high nucleophilicity,frequency,and solvent accessibility,making its site-selective modification im-portant but elusive.Herein,we reported a visible-light-driven and Cys-directed Lys site-selective stapling approach for peptide/protein.By cleavable Cys anchoring,site-selective Lys single-site modification was achieved,and this method could be applied to multi-functionalization.
文献关键词:
中图分类号:
作者姓名:
Jian Li;Qi-Long Hu;Zhendong Song;Albert S.C.Chan;Xiao-Feng Xiong
作者机构:
Guangdong Key Laboratory of Chiral Molecule and Drug Discovery,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China
文献出处:
引用格式:
[1]Jian Li;Qi-Long Hu;Zhendong Song;Albert S.C.Chan;Xiao-Feng Xiong-.Cleavable Cys labeling directed Lys site-selective stapling and single-site modification)[J].中国科学:化学(英文版),2022(07):1356-1361
A类:
Cleavable,stapling,nucleophilicity
B类:
Cys,labeling,directed,site,selective,single,Site,peptide,protein,vital,approach,disclose,post,translational,modifications,PTMs,plays,crucial,role,chemical,biology,well,drug,development,Compared,synthetic,methods,native,provides,more,versatile,late,stage,diversification,studies,Lysine,featured,high,frequency,solvent,accessibility,making,its,im,portant,but,elusive,Herein,reported,visible,light,driven,By,cleavable,anchoring,was,achieved,this,could,applied,multi,functionalization
AB值:
0.561958
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