典型文献
Dynamics and biological relevance of epigenetic N6-methyladenine DNA modification in eukaryotic cells
文献摘要：
DNA methylation represents a major type of DNA modifications that play key roles in diverse biolog-ical processes.With the recent development of highly selective and sensitive bioanalytical techniques,N6-methyladenine(6mA)has been characterized as an important internal DNA modification dynamically occurring in multiple eukaryotes including humans.Increasing evidence has indicated that 6mA may act as a novel epigenetic modification involved in regulation of development,stress response and diseases such as cancer and neurodegenerative disorders.We review herein the recent advances in the detec-tion and functional studies of 6mA modification,with special emphasis on its biological consequences and human health relevance as well as its dynamic regulation by various types of methyltransferases,demethylases and 6mA-binding proteins.It can be envisaged that further chemical and biological studies of 6mA modification will lead to a better understanding about its potentially important roles in normal and pathological biological processes.
文献关键词：
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作者姓名：
Yuwei Sheng;Meijuan Zhou;Changjun You;Xiaoxia Dai
作者机构：
State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Molecular Science and Biomedicine Laboratory,Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology,Hunan University,Changsha 410082,China
文献出处：
引用格式：
[1]Yuwei Sheng;Meijuan Zhou;Changjun You;Xiaoxia Dai-.Dynamics and biological relevance of epigenetic N6-methyladenine DNA modification in eukaryotic cells)[J].中国化学快报（英文版）,2022(05):2253-2258
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Dynamics,biological,relevance,epigenetic,N6,methyladenine,eukaryotic,cells,methylation,represents,major,modifications,that,play,key,roles,diverse,processes,With,recent,development,highly,selective,sensitive,bioanalytical,techniques,6mA,been,characterized,important,internal,dynamically,occurring,multiple,eukaryotes,including,humans,Increasing,evidence,indicated,may,novel,involved,regulation,stress,response,diseases,such,cancer,neurodegenerative,disorders,We,review,herein,advances,detec,functional,studies,special,emphasis,its,consequences,health,well,by,various,types,methyltransferases,demethylases,binding,proteins,It,envisaged,further,chemical,will,lead,better,understanding,about,potentially,normal,pathological
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0.593944
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