典型文献
Update on Mayer-Rokitansky-Küster-Hauser syndrome
文献摘要：
This review presents an update of Mayer-Rokitansky-K(us)ter-Hauser(MRKH)syndrome on its etiologic,clinical,diagnostic,psychological,therapeutic,and reproductive aspects.The etiology of MRKH syndrome remains unclear due to its intrinsic heterogeneity.Nongenetic and genetic causes that may interact during the embryonic development have been proposed with no definitive etiopathogenesis identified.The proportion of concomitant extragenital malformations varies in different studies,and the discrepancies may be explained by ethnic differences.In addition to physical examination and pelvic ultrasound,the performance of pelvic magnetic resonance imaging is crucial in detecting the presence of rudimentary uterine endometrium.MRKH syndrome has long-lasting psychological effects on patients,resulting in low esteem,poor coping strategies,depression,and anxiety symptoms.Providing psychological counseling and peer support to diagnosed patients is recommended.Proper and timely psychological intervention could significantly improve a patient's outcome.Various nonsurgical and surgical methods have been suggested for treatment of MRKH syndrome.Due to the high success rate and minimal risk of complications,vaginal dilation has been proven to be the first-line therapy.Vaginoplasty is the second-line option for patients experiencing dilation failure.Uterine transplantation and gestational surrogacy are options for women with MRKH syndrome to achieve biological motherhood.
文献关键词：
中图分类号：
作者姓名：
Na Chen;Shuang Song;Xinmiao Bao;Lan Zhu
作者机构：
National Clinical Research Center for Obstetric and Gynecologic Diseases,Department of Obstetrics and Gynecology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China;Peking Union Medical College,M.D.Program,Beijing 100730,China
文献出处：
引用格式：
[1]Na Chen;Shuang Song;Xinmiao Bao;Lan Zhu-.Update on Mayer-Rokitansky-Küster-Hauser syndrome)[J].医学前沿,2022(06):859-872
A类：
Nongenetic,etiopathogenesis,extragenital,Vaginoplasty,surrogacy,motherhood
B类：
Update,Mayer,Rokitansky,ster,Hauser,syndrome,This,review,presents,update,MRKH,its,etiologic,clinical,diagnostic,psychological,therapeutic,reproductive,aspects,etiology,remains,unclear,due,intrinsic,heterogeneity,causes,that,may,interact,during,embryonic,development,have,been,proposed,definitive,identified,proportion,concomitant,malformations,varies,different,studies,discrepancies,explained,by,ethnic,differences,In,addition,physical,examination,pelvic,ultrasound,performance,magnetic,resonance,imaging,crucial,detecting,presence,rudimentary,uterine,endometrium,has,long,lasting,effects,patients,resulting,low,esteem,poor,coping,strategies,depression,anxiety,symptoms,Providing,counseling,peer,support,diagnosed,recommended,Proper,timely,intervention,could,significantly,improve,outcome,Various,nonsurgical,methods,suggested,treatment,Due,high,success,minimal,risk,complications,vaginal,dilation,proven,first,line,therapy,second,experiencing,failure,Uterine,transplantation,gestational,are,options,women,achieve,biological
AB值：
0.635065
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
