典型文献
Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia
文献摘要：
Few studies have described the key features and prognostic roles of lung microbiota in patients with severe community-acquired pneumonia(SCAP).We prospectively enrolled consecutive SCAP patients admitted to ICU.Bronchoscopy was performed at bedside within 48 h of ICU admission,and 16S rRNA gene sequencing was applied to the collected bronchoalveolar lavage fluid.The primary outcome was clinical improvements defined as a decrease of 2 categories and above on a 7-category ordinal scale within 14 days following bronchoscopy.Sixty-seven patients were included.Multivariable permutational multivariate analysis of variance found that positive bacteria lab test results had the strongest independent association with lung microbiota(R2=0.033;P=0.018),followed by acute kidney injury(AKI;R2=0.032;P=0.011)and plasma MIP-1β level(R2=0.027;P=0.044).Random forest identified that the families Prevotellaceae,Moraxellaceae,and Staphylococcaceae were the biomarkers related to the positive bacteria lab test results.Multivariable Cox regression showed that the increase in α-diversity and the abundance of the families Prevotellaceae and Actinomycetaceae were associated with clinical improvements.The positive bacteria lab test results,AKI,and plasma MIP-1β level were associated with patients'lung microbiota composition on ICU admission.The families Prevotellaceae and Actinomycetaceae on admission predicted clinical improvements.
文献关键词：
中图分类号：
作者姓名：
Sisi Du;Xiaojing Wu;Binbin Li;Yimin Wang;Lianhan Shang;Xu Huang;Yudi Xia;Donghao Yu;Naicong Lu;Zhibo Liu;Chunlei Wang;Xinmeng Liu;Zhujia Xiong;Xiaohui Zou;Binghuai Lu;Yingmei Liu;Qingyuan Zhan;Bin Cao
作者机构：
China-Japan Friendship Hospital,National Clinical Research Center for Respiratory Diseases,National Center for Respiratory Medicine,Clinical Center for Pulmonary Infections,Capital Medical University,Beijing 100029,China;Institute of Respiratory Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100029,China;Department of Pulmonary and Critical Care Medicine,Center for Respiratory Diseases,China-Japan Friendship Hospital,Beijing 100029,China;Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Luhe Hospital,Beijing 101100,China;Tsinghua University-Peking University Joint Center for Life Sciences,Beijing 100084,China
文献出处：
引用格式：
[1]Sisi Du;Xiaojing Wu;Binbin Li;Yimin Wang;Lianhan Shang;Xu Huang;Yudi Xia;Donghao Yu;Naicong Lu;Zhibo Liu;Chunlei Wang;Xinmeng Liu;Zhujia Xiong;Xiaohui Zou;Binghuai Lu;Yingmei Liu;Qingyuan Zhan;Bin Cao-.Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia)[J].医学前沿,2022(03):389-402
A类：
permutational,Moraxellaceae,Staphylococcaceae,Actinomycetaceae
B类：
Clinical,factors,associated,composition,lung,microbiota,important,taxa,predicting,clinical,prognosis,patients,severe,community,acquired,pneumonia,Few,studies,have,described,key,features,prognostic,roles,SCAP,We,prospectively,enrolled,consecutive,admitted,ICU,Bronchoscopy,was,performed,bedside,within,admission,16S,rRNA,gene,sequencing,applied,collected,bronchoalveolar,lavage,fluid,primary,outcome,improvements,defined,decrease,categories,above,category,ordinal,scale,days,following,bronchoscopy,Sixty,seven,were,included,Multivariable,multivariate,analysis,variance,found,that,positive,bacteria,lab,test,results,had,strongest,independent,association,followed,by,acute,kidney,injury,AKI,plasma,MIP,level,Random,forest,identified,families,Prevotellaceae,biomarkers,related,Cox,regression,showed,increase,diversity,abundance,predicted
AB值：
0.543516
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