典型文献
Fine-tuning cell organelle dynamics during mitosis by small GTPases
文献摘要：
During mitosis,the allocation of genetic material concurs with organelle transformation and distribution.The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression,cell fate determination,and organismal homeostasis.Small GTPases belonging to the Ras superfamily regulate various cell organelles during division.Being the key regulators of membrane dynamics,the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases,such as cancer and Alzheimer's disease.Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation.This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.
文献关键词：
中图分类号：
作者姓名：
Zijian Zhang;Wei Zhang;Quentin Liu
作者机构：
Sun Yat-sen University Cancer Center;State Key Laboratory of Oncology in South China;Collaborative Innovation Center for Cancer Medicine,Guangzhou 510060,China;Department of Clinical Immunology,The Third Affiliated Hospital,Sun Yat-sen University, Guangzhou 510630,China;Institute of Cancer Stem Cell,Dalian Medical University,Dalian 116044,China
文献出处：
引用格式：
[1]Zijian Zhang;Wei Zhang;Quentin Liu-.Fine-tuning cell organelle dynamics during mitosis by small GTPases)[J].医学前沿,2022(03):339-357
A类：
concurs,adaptors
B类：
Fine,tuning,cell,dynamics,during,mitosis,by,small,GTPases,During,allocation,genetic,material,transformation,distribution,coordination,inheritance,directs,accurate,mitotic,progression,fate,determination,organismal,homeostasis,Small,belonging,Ras,superfamily,regulate,various,organelles,division,Being,key,regulators,membrane,dysregulation,widely,associated,disruption,neoplastic,diseases,such,cancer,Alzheimer,Recent,discoveries,shed,molecular,properties,sophisticated,modulators,remarkably,complex,perfect,rapid,structure,reformation,This,review,collects,current,knowledge,highlights,mediator,role,transducing,cycle,signaling
AB值：
0.56245
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