典型文献
The roles of intraflagellar transport(IFT)protein 25 in mammalian signaling transduction and flagellogenesis
文献摘要:
Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling compartment.During ciliogenesis,ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport(IFT)particles,where the inner counterparts undergo reverse trafficking.The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction.Much progress has been made on the mechanisms and functions of IFT;however,recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis.In this review,we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.
文献关键词:
中图分类号:
作者姓名:
Yong-Hong Man;Isabella Warmbrunn;Ling Zhang;Zhi-Bing Zhang
作者机构:
Department of Occupational and Environmental Medicine,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,China;Center of Scientific Research and Experiment,Nanyang Medical College,Nanyang 473006,China;Department of Physiology,Wayne State University School of Medicine,Detroit,Ml 48201,USA;Department of Obstetrics and Gynecology,Wayne State University School of Medicine,Detroit,Ml 48201,USA
文献出处:
引用格式:
[1]Yong-Hong Man;Isabella Warmbrunn;Ling Zhang;Zhi-Bing Zhang-.The roles of intraflagellar transport(IFT)protein 25 in mammalian signaling transduction and flagellogenesis)[J].亚洲男性学杂志(英文版),2022(03):238-242
A类:
intraflagellar,flagellogenesis,Cilium,cilial,IFT25
B类:
roles,mammalian,signaling,transduction,organelle,unique,proteome,organization,protruding,from,cell,surface,generally,serves,force,generator,compartment,During,ciliogenesis,ciliary,proteins,are,synthesized,cytoplasm,transported,into,by,particles,where,inner,counterparts,undergo,reverse,trafficking,homeostasis,plays,key,structure,assembly,Much,progress,has,been,made,mechanisms,functions,however,recent,studies,have,revealed,involvement,subunits,organogenesis,spermatogenesis,In,this,review,discuss,new,concepts,concerning,molecular,interactions,other,involved,development,fertility
AB值:
0.561134
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