典型文献
The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed;many more still need an answer
文献摘要：
Crimean-Congo hemorrhagic fever virus(CCHFV)is regarded as one of the most deadly viruses,with mortality of up to 40％.Currently,no licensed vaccine with validated efficacy against CCHFV is available.CCHFV uses Gn and Gc glycoproteins to bind and penetrate the cell,like other bunyaviruses(Hulswit et al.,2021).Thus,the desired vaccines are needed,to elicit a potent neutralizing antibody(NAb)response to counteract this process.The only target for NAb recognition is Gc,a typical type Ⅱ membrane fusion protein like flavivirus E protein(Modis et al.,2003).However,the administration of NAb targeting CCHFV Gc after one day post-challenge cannot provide protection in a lethal murine model(Fels et al.,2021).
文献关键词：
中图分类号：
作者姓名：
Wei Ye;Chuantao Ye;Yongliang Hu;Yangchao Dong;Yingfeng Lei;Fanglin Zhang
作者机构：
Department of Microbiology,School of Preclinical Medicine,Airforce Medical University:Fourth Military Medical University,Xi'an,710032,China;Department of Infectious Diseases,Tangdu Hospital,Airforce Medical University:Fourth Military Medical University,Xi'an,710038,China;Department of Dermatology,The Eighth Medical Center of PLA General Hospital,Beijing,100091,China
文献出处：
引用格式：
[1]Wei Ye;Chuantao Ye;Yongliang Hu;Yangchao Dong;Yingfeng Lei;Fanglin Zhang-.The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed;many more still need an answer)[J].中国病毒学,2022(04):634-636
A类：
bunyaviruses,Hulswit,Modis,Fels
B类：
structure,Crimean,Congo,hemorrhagic,fever,Gc,revealed,many,more,still,answer,CCHFV,regarded,as,one,most,deadly,mortality,up,Currently,licensed,validated,efficacy,against,available,Gn,glycoproteins,bind,penetrate,cell,like,other,Thus,desired,vaccines,are,needed,elicit,potent,neutralizing,antibody,NAb,response,counteract,this,process,only,recognition,typical,type,membrane,fusion,flavivirus,However,administration,targeting,after,day,post,challenge,cannot,provide,protection,lethal,murine,model
AB值：
0.555385
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
