典型文献
Consolidation treatment needed for sustained HBsAg-negative response induced by interferon-alpha in HBeAg positive chronic hepatitis B patients
文献摘要：
Hepatitis B surface antigen(HBsAg)clearance is considered as functional cure in patients with chronic hepatitis B(CHB).This study aimed to assess the durability of HBsAg clearance achieved by interferon-based therapies in patients with CHB who were originally positive for hepatitis B envelope antigen(HBeAg).In this prospective study,HBeAg-positive CHB patients with confirmed HBsAg loss under interferon-based therapies were enrolled within 12 weeks from end of treatment and followed up for 48 weeks.Virological markers,biochemical in-dicators,and liver imaging examinations were observed every 3-6 months.Sustained functional cure was ana-lysed as primary outcome.Factor associated with sustained HBsAg loss or reversion was also investigated.The rate of HBsAg loss sustainability was 91.8％(212/231).Patients receiving consolidation treatment for 12-24 weeks or≥24 weeks had higher rates of sustained HBsAg negativity than those receiving consolidation treatment for＜12 weeks(98.3％and 91.2％vs.86.7％,P=0.068),and the former groups had significantly higher anti-HBs levels than the later(P＜0.05).The cumulative incidence of HBsAg reversion and HBV DNA reversion was 8.2％and 3.9％,respectively.Consolidation treatment of≥12 weeks[odd ratio(OR)3.318,95％confidence interval(CI)1.077-10.224,P=0.037)was a predictor of sustained functional cure,and HBeAg-positivity at cessation of treatment(OR 12.271,95％CI 1.076-139.919,P=0.043)was a predictor of HBsAg reversion.Interferon-alpha induced functional cure was durable and a consolidation treatment of≥12-24 weeks was needed after HBsAg loss in HBeAg-positive CHB patients.
文献关键词：
中图分类号：
作者姓名：
Minghui Li;Fangfang Sun;Xiaoyue Bi;Yanjie Lin;Liu Yang;Yao Lu;Lu Zhang;Gang Wan;Wei Yi;Linqing Zhao;Yao Xie
作者机构：
Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China;Department of Biostatistics,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Department of Gynecology and Obstetrics,Beijing Ditan Hospital,Capital Medical University,Beijing,100015,China;Laboratory of Virology,Beijing Key Laboratory of Etiology of Viral Diseases in Children,Capital Institute of Pediatrics,Beijing,100020,China
文献出处：
引用格式：
[1]Minghui Li;Fangfang Sun;Xiaoyue Bi;Yanjie Lin;Liu Yang;Yao Lu;Lu Zhang;Gang Wan;Wei Yi;Linqing Zhao;Yao Xie-.Consolidation treatment needed for sustained HBsAg-negative response induced by interferon-alpha in HBeAg positive chronic hepatitis B patients)[J].中国病毒学,2022(03):390-397
A类：
Virological,lysed
B类：
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AB值：
0.461173
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