典型文献
Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis
文献摘要：
Background::Psoriasis is a chronic systemic inflammatory disease, and hyperuricemia is a common comorbidity in patients with psoriasis. However, there are limited reports on the relationship between serum uric acid levels and biological treatment efficacy. The purposes of this study were to compare the differences in serum uric acid levels between patients with psoriasis and healthy controls and analyze the risk of hyperuricemia.Methods::A total of 196 patients with psoriasis and 191 age- and sex-matched healthy controls were enrolled in this retrospective cohort study. One hundred and twenty-seven patients with severe psoriasis were treated with biologics. Sixty-eight patients received adalimumab, and 59 patients received secukinumab. Serum uric acid levels were measured at baseline, week 24, and week 48 of treatment.Results::Patients with psoriasis had higher serum uric acid levels than healthy controls (6.4 ± 1.7 mg/dL
vs. 5.7 ± 1.5 mg/dL,
P < 0.001). Hyperuricemia was found in 33.7% (66/196) of patients with psoriasis, which was significantly higher than that in healthy controls (13.1% [25/191],
P < 0.001). Serum uric acid levels and hyperuricemia were not related to the severity of psoriasis (
P > 0.05). No significant changes in serum uric acid levels and hyperuricemia were observed following adalimumab treatment (
P > 0.05). The serum uric acid level in patients treated with secukinumab was 6.7 ± 1.6 mg/dL at week 24, which was not statistically different from that at baseline (6.6 ± 1.4 mg/dL,
P = 0.885). Serum uric acid levels were significantly decreased at week 48 (6.3 ± 1.5 mg/dL
vs. 6.6 ± 1.4 mg/dL,
P = 0.007) in patients treated with secukinumab. Secukinumab had no significant effect on hyperuricemia either (
P > 0.05).
Conclusions::The serum uric acid levels and prevalence of hyperuricemia in patients with psoriasis were significantly higher than those in healthy controls. Secukinumab treatment for 48 weeks successfully decreased serum uric acid levels in patients with psoriasis, whereas adalimumab had no significant effect on serum uric acid levels.
文献关键词：
Psoriasis;Serum uric acid;Adalimumab;Secukinumab;Hyperuricemia
中图分类号：
作者姓名：
Zhao Zheng;Cai Lin;Zhang Si;Zhang Heng;Liu Xiaoyang;Li Chenglong;Zhao Yan;Zhang Jianzhong
作者机构：
Department of Dermatology, Peking University People’s Hospital, Beijing 100044, China;Department of Dermatology, Peking University International Hospital, Beijing 102206, China;Peking University Clinical Research Institute, Beijing 100191, China
文献出处：
引用格式：
[1]Zhao Zheng;Cai Lin;Zhang Si;Zhang Heng;Liu Xiaoyang;Li Chenglong;Zhao Yan;Zhang Jianzhong-.Effects of secukinumab and adalimumab on serum uric acid level in patients with plaque psoriasis)[J].中华医学杂志（英文版）,2022(12):1438-1443
A类：
Secukinumab,Adalimumab
B类：
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AB值：
0.330653
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