典型文献
Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019
文献摘要：
During 2018-2019,a severe human adenovirus(HAdV)infection outbreak occurred in southern China.Here,we screened 18 respiratory pathogens in 1704 children(≤14 years old)hospitalized with acute respiratory illness in Guangzhou,China,in 2019.In total,151 patients had positive HAdV test results;34.4％(52/151)of them exhibited severe illness.HAdV infection occurred throughout the year,with a peak in summer.The median pa-tient age was 3.0(interquartile range:1.1-5.0)years.Patients with severe HAdV infection exhibited increases in 12 clinical indexes(P≤0.019)and decreases in four indexes(P≤0.007),compared with patients exhibiting non-severe infection.No significant differences were found in age or sex distribution according to HAdV infection severity(P＞0.05);however,the distributions of comorbid disease and HAdV co-infection differed according to HAdV infection severity(P＜0.05).The main epidemic types were HAdV-3(47.0％,71/151)and HAdV-7(46.4％,70/151).However,the severe illness rate was significantly higher in patients with HAdV-7(51.4％)than in patients with HAdV-3(19.7％)and other types of HAdV(20％)(P＜0.001).Sequencing analysis of genomes/capsid genes of 13 HAdV-7 isolates revealed high similarity to previous Chinese isolates.A representative HAdV-7 isolate exhibited a similar proliferation curve to the curve described for the epidemic HAdV-3 strain Guangzhou01(accession no.DQ099432)(P＞0.05);the HAdV-7 isolate exhibited stronger virulence and infectivity,compared with HAdV-3(P＜0.001).Overall,comorbid disease,HAdV co-infection,and high virulence and infectivity of HAdV-7 were critical risk factors for severe HAdV infection;these data can facilitate treatment,control,and prevention of HAdV infection.
文献关键词：
中图分类号：
作者姓名：
Wenkuan Liua;Shuyan Qiua;Li Zhang;Hongkai Wu;Xingui Tian;Xiao Li;Duo Xu;Jing Dai;Shujun Gu;Qian Liu;Dehui Chen;Rong Zhou
作者机构：
State Key Laboratory of Respiratory Diseases,National Clinical Research Center for Respiratory Disease,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Health,Guangzhou Medical University,Guangzhou,510040,China;Scientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangzhou,510062,China;Bioland Laboratory,Guangzhou Laboratory,Guangzhou,510320,China
文献出处：
引用格式：
[1]Wenkuan Liua;Shuyan Qiua;Li Zhang;Hongkai Wu;Xingui Tian;Xiao Li;Duo Xu;Jing Dai;Shujun Gu;Qian Liu;Dehui Chen;Rong Zhou-.Analysis of severe human adenovirus infection outbreak in Guangdong Province,southern China in 2019)[J].中国病毒学,2022(03):331-340
A类：
Guangzhou01,DQ099432
B类：
Analysis,severe,human,adenovirus,infection,outbreak,Guangdong,Province,southern,China,During,HAdV,occurred,Here,screened,respiratory,pathogens,children,years,old,hospitalized,acute,illness,In,total,patients,had,positive,test,results,them,exhibited,throughout,peak,summer,median,age,was,interquartile,range,Patients,increases,clinical,indexes,decreases,four,compared,exhibiting,No,differences,were,found,sex,according,severity,however,distributions,comorbid,disease,differed,main,epidemic,types,However,rate,significantly,higher,than,other,Sequencing,analysis,genomes,capsid,genes,isolates,revealed,similarity,previous,Chinese,representative,proliferation,curve,described,strain,accession,stronger,virulence,infectivity,Overall,critical,risk,factors,these,data,facilitate,treatment,control,prevention
AB值：
0.442356
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