典型文献
"Progressive motility"in elucidating novel genetic causes of male infertility
文献摘要：
Genetic factors play important roles in the etiology of male infertility.The routine clinical genetic testing for human spermatogenic failure is currently limited to abnormal karyotypes(e.g.,47,XXY for Klinefelter syndrome)and Y chromosomal microdeletions.1 However,these chromosomal variants only account for approximately 20％of the infertile males with nonobstructive azoospermia.The vast majority of male infertile cases are genetically unexplained.1 With the recent advances in genomic technologies,the genome-wide dissections at the nucleotide resolution have been achieved,and the novel genetic factors involved in human male infertility have been continuously uncovered.Furthermore,the methodological progresses in gene manipulation(e.g.,clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9[CRISPR/Cas9])and animal modeling facilitate functional verifications for the genetic etiology of male infertility.This special issue,"Genetics of Male Infertility",contains two reviews,five original articles,and one commentary to introduce some recent research progresses in the genetic field of male infertility.
文献关键词：
中图分类号：
作者姓名：
Feng Zhang
作者机构：
Institute of Reproduction and Development,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China;State Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai 200438,China;Human Phenome Institute,Zhangjiang Fudan International Innovation Center,Fudan University,Shanghai 201203,China
文献出处：
引用格式：
[1]Feng Zhang-."Progressive motility"in elucidating novel genetic causes of male infertility)[J].亚洲男性学杂志（英文版）,2022(03):229-230
A类：
karyotypes,microdeletions,nonobstructive
B类：
Progressive,motility,elucidating,novel,causes,infertility,factors,play,important,roles,etiology,routine,clinical,testing,human,spermatogenic,failure,currently,limited,abnormal,XXY,Klinefelter,syndrome,chromosomal,However,these,variants,only,account,approximately,infertile,males,azoospermia,vast,majority,cases,are,genetically,unexplained,With,recent,advances,genomic,technologies,genome,wide,dissections,nucleotide,resolution,have,been,achieved,involved,continuously,uncovered,Furthermore,methodological,progresses,manipulation,clustered,regularly,interspaced,short,palindromic,repeats,CRISPR,associated,protein,Cas9,animal,modeling,facilitate,functional,verifications,This,special,issue,Genetics,Male,Infertility,contains,two,reviews,five,original,articles,one,commentary,introduce,some,research,field
AB值：
0.651704
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