BACKGROUND Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardi-ovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown. METHODS The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrument-al variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large, previously described cohorts. Association between thyroid function and essential hypertension (EHTN), secondary hypertension (SHTN), hyperlipidemia (HPL), type 2 diabetes mellitus (T2DM), ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), pulmonary heart disease (PHD), stroke, and non-rheumatic valve disease (NRVD) were examined. RESULTS Genetically predicted FT4 levels were associated with SHTN (odds ratio = 0.48; 95％ CI = 0.04?0.82, P = 0.027), HPL (odds ratio = 0.67; 95％ CI = 0.18?0.88, P = 0.023), T2DM (odds ratio = 0.80; 95％ CI = 0.42?0.86, P = 0.005), IHD (odds ratio = 0.85;95％ CI = 0.49?0.98, P = 0.039), NRVD (odds ratio = 0.75; 95％ CI = 0.27?0.97, P = 0.039). Additionally, genetically predicted TSH levels were associated with HF (odds ratio = 0.82; 95％ CI = 0.68?0.99, P = 0.042), PHD (odds ratio = 0.75; 95％ CI = 0.32?0.82, P =0.006), stroke (odds ratio = 0.95; 95％ CI = 0.81?0.97, P = 0.007). However, genetically predicted thyroid function traits were not as-sociated with EHTN and MI. CONCLUSIONS Our study suggests FT4 and TSH are associated with cardiometabolic diseases, underscoring the importance of the pituitary-thyroid-cardiac axis in cardiometabolic health susceptibility.

Jing-Jia WANG;Zhen-Huang ZHUANG;Can-Qing YU;Wen-Yao WANG;Wen-Xiu WANG;Kuo ZHANG;Xiang-Bin MENG;Jun GAO;Jian TIAN;Ji-Lin ZHENG;Jie YANG;Tao HUANG;Chun-Li SHAO;Yi-Da TANG

Department of Cardiology,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Department of Epidemiology&Biostatistics,School of Public Health,Peking University,Beijing,China;Center for Intelligent Public Health,Academy for Artificial Intelligence,Peking University,Beijing,China;Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Beijing,China;Key Laboratory of Molecular Cardiovascular Sciences(Peking University),Ministry of Education,Beijing,China

老年心脏病学杂志（英文版）

[1]Jing-Jia WANG;Zhen-Huang ZHUANG;Can-Qing YU;Wen-Yao WANG;Wen-Xiu WANG;Kuo ZHANG;Xiang-Bin MENG;Jun GAO;Jian TIAN;Ji-Lin ZHENG;Jie YANG;Tao HUANG;Chun-Li SHAO;Yi-Da TANG-.Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study)[J].老年心脏病学杂志（英文版）,2022(01):61-70

cardi,ovascular,FinnGen,CARDIoGRAM,CARDIoGRAMplusC4D,MEGASTROKE,EHTN,SHTN,NRVD

Assessment,causal,direction,between,thyroid,function,cardiometabolic,health,Mendelian,randomization,study,BACKGROUND,Growing,evidence,have,demonstrated,that,hormones,been,involved,processes,metabolism,However,remains,partly,unknown,METHODS,MR,was,used,test,potentially,relationships,variables,traits,variants,free,thyroxine,FT4,thyrotropin,TSH,levels,within,reference,range,were,instrumental,Data,associations,diseases,acquired,from,genome,wide,studies,CHARGE,This,conducted,using,summary,statistic,data,large,previously,described,cohorts,Association,essential,hypertension,secondary,hyperlipidemia,HPL,type,diabetes,mellitus,T2DM,ischemic,heart,IHD,myocardial,infarction,MI,failure,HF,pulmonary,PHD,stroke,rheumatic,valve,examined,RESULTS,Genetically,predicted,associated,odds,ratio,Additionally,genetically,not,CONCLUSIONS,Our,suggests,are,underscoring,importance,pituitary,cardiac,axis,susceptibility

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