典型文献
Updates in endocrine therapy for metastatic breast cancer
文献摘要：
Endocrine therapy (ET) remains the mainstay of treatment for steroid hormone receptor-positive, human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (MBC). Tumor resistance to hormone therapy has led to the development of novel endocrine drug combinations, transforming the landscape of MBC management. The options for ET are expanding, with promising agents in the pipeline. Although MBC remains incurable, many patients can enjoy years of survival with good quality of life by cycling through the many available agents. With the plethora of available agents and rapid approvals, clinicians look to evidence-based guidelines to assist in treatment selection to maximize patient well-being. In this review, we provide a contemporary review of the advances in ET and a suggested algorithm to guide clinicians in daily management of patients with hormone receptor-positive, HER2-negative MBC. We will discuss landmark trials and highlight their impact in reshaping treatment approaches. Finally, we will provide a glimpse into advances on the horizon and the promise they bring to improve outcomes in patients with advanced breast cancer.
文献关键词：
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作者姓名：
Poorni M.Manohar;Nancy E.Davidson
作者机构：
University of Washington/Seattle Cancer Care Alliance,Seattle 98109,WA,USA;Fred Hutchinson Cancer Research Center,Seattle 98109,WA,USA
文献出处：
引用格式：
[1]Poorni M.Manohar;Nancy E.Davidson-.Updates in endocrine therapy for metastatic breast cancer)[J].癌症生物学与医学（英文版）,2022(02):202-212
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0.626743
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