典型文献
Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
文献摘要：
The use of small interfering RNAs(siRNAs)has been under investigation for the treatment of several unmet medical needs,including acute lung injury/acute respiratory distress syndrome(ALI/ARDS)wherein siRNA may be implemented to modify the expression of pro-inflammatory cytokines and chemokines at the mRNA level.The properties such as clear anatomy,accessibility,and relatively low enzyme activity make the lung a good target for local siRNA therapy.However,the translation of siRNA is restricted by the inefficient delivery of siRNA therapeutics to the target cells due to the prop-erties of naked siRNA.Thus,this review will focus on the various delivery systems that can be used and the different barriers that need to be surmounted for the development of stable inhalable siRNA formu-lations for human use before siRNA therapeutics for ALI/ARDS become available in the clinic.
文献关键词：
中图分类号：
作者姓名：
Makhloufi Zoulikha;Qingqing Xiao;George Frimpong Boafo;Marwa A.Sallam;Zhongjian Chen;Wei He
作者机构：
Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Department of Industrial Pharmacy,Faculty of Pharmacy,Alexandria University,Alexandria 21521,Egypt;Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China
文献出处：
引用格式：
[1]Makhloufi Zoulikha;Qingqing Xiao;George Frimpong Boafo;Marwa A.Sallam;Zhongjian Chen;Wei He-.Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome)[J].药学学报（英文版）,2022(02):600-620
A类：
surmounted
B类：
Pulmonary,delivery,against,acute,lung,injury,respiratory,distress,syndrome,small,interfering,siRNAs,has,been,under,investigation,treatment,several,unmet,medical,needs,including,ALI,ARDS,wherein,may,implemented,modify,expression,inflammatory,cytokines,chemokines,level,properties,such,clear,anatomy,accessibility,relatively,low,enzyme,activity,make,good,target,local,therapy,However,translation,restricted,by,inefficient,therapeutics,cells,due,naked,Thus,this,review,will,focus,various,systems,that,can,used,different,barriers,development,stable,inhalable,formu,lations,human,before,become,available,clinic
AB值：
0.601972
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
