典型文献
Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages
文献摘要：
Objective: Although great progress has been made in the field of siRNA gene therapy, safe, efficient, and targeted delivery of siRNA are still major challenges in siRNA therapeutics.Methods: We developed an up-conversion nanoparticle-based nanocage system. This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites, due to modifications of targeted molecules on the surfaces of nanocages and local inhalation. Results: The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites, where they accumulated. Compared with the passive target and control groups, the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of treatment. Conclusions: The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor sites. Mice with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes, high tumor inhibition ratios, and longer survival times.
文献关键词：
中图分类号：
作者姓名：
Yu Han;Yuming Yang;Qiuyang Sun;Bin Li;Caixia Yue;Yanlei Liu;Jesús M.de la Fuente;Daxiang Cui
作者机构：
Institute of Nano Biomedicine and Engineering,Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education,Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument,Department of Instrument Science&Engineering,School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;National Engineering Center for Nanotechnology,Collaborative Innovational Center for System Biology,Shanghai 200241,China;Department of Neurosurgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China;School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Instituto de Nanociencia de Aragon(INA),Universidad de Zaragoza,Zaragoza 50018,Spain
文献出处：
引用格式：
[1]Yu Han;Yuming Yang;Qiuyang Sun;Bin Li;Caixia Yue;Yanlei Liu;Jesús M.de la Fuente;Daxiang Cui-.Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages)[J].癌症生物学与医学（英文版）,2022(07):1047-1060
A类：
B类：
Dual,targeted,lung,cancer,therapy,via,inhalation,delivery,UCNP,AS1411,nanocages,Objective,Although,great,progress,has,been,made,field,gene,safe,still,major,challenges,therapeutics,Methods,We,developed,conversion,system,This,protected,from,being,degraded,by,nucleases,organisms,selectively,delivered,siRNAs,sites,due,modifications,molecules,surfaces,local,Results,were,degradation,transit,where,they,accumulated,Compared,passive,control,groups,nanoparticles,showed,suppressive,effect,after,approximately,weeks,treatment,Conclusions,efficiently,vascular,endothelial,growth,Mice,tumors,treated,targeting,steady,body,weight,changes,high,inhibition,ratios,longer,survival,times
AB值：
0.543127
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